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dc.contributor.authorWang, Xiaorongen_US
dc.contributor.authorYano, Eijien_US
dc.contributor.authorLin, Sihaoen_US
dc.contributor.authorYu, Ignatius T. S.en_US
dc.contributor.authorLan, Yajiaen_US
dc.contributor.authorTse, Lap Ahen_US
dc.contributor.authorQiu, Hongen_US
dc.contributor.authorChristiani, David C.en_US
dc.date.accessioned2014-03-01T02:23:57Z
dc.date.issued2013en_US
dc.identifier.citationWang, Xiaorong, Eiji Yano, Sihao Lin, Ignatius T. S. Yu, Yajia Lan, Lap Ah Tse, Hong Qiu, and David C. Christiani. 2013. “Cancer Mortality in Chinese Chrysotile Asbestos Miners: Exposure-Response Relationships.” PLoS ONE 8 (8): e71899. doi:10.1371/journal.pone.0071899. http://dx.doi.org/10.1371/journal.pone.0071899.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855739
dc.description.abstractObjective: This study was conducted to assess the relationship of mortality from lung cancer and other selected causes to asbestos exposure levels. Methods: A cohort of 1539 male workers from a chrysotile mine in China was followed for 26 years. Data on vital status, occupation and smoking were collected from the mine records and individual contacts. Causes and dates of death were further verified from the local death registry. Individual cumulative fibre exposures (f-yr/ml) were estimated based on converted dust measurements and working years at specific workshops. Standardized mortality ratios (SMRs) for lung cancer, gastrointestinal (GI) cancer, all cancers and nonmalignant respiratory diseases (NMRD) stratified by employment years, estimated cumulative fibre exposures, and smoking, were calculated. Poisson models were fitted to determine exposure-response relationships between estimated fibre exposures and cause-specific mortality, adjusting for age and smoking. Results: SMRs for lung cancer increased with employment years at entry to the study, by 3.5-fold in ≥10 years and 5.3-fold in ≥20 years compared with <10 years. A similar trend was seen for NMRD. Smokers had greater mortality from all causes than nonsmokers, but the latter also had slightly increased SMR for lung cancer. No excess lung cancer mortality was observed in cumulative exposures of <20 f-yrs/ml. However, significantly increased mortality was observed in smokers at the levels of ≥20 f-yrs/ml and above, and in nonsmokers at ≥100 f-yrs/ml and above. A similarly clear gradient was also displayed for NMRD. The exposure-response relationships with lung cancer and NMRD persisted in multivariate analysis. Moreover, a clear gradient was shown in GI cancer mortality when age and smoking were adjusted for. Conclusion: There were clear exposure-response relationships in this cohort, which imply a causal link between chrysotile asbestos exposure and lung cancer and nonmalignant respiratory diseases, and possibly to gastrointestinal cancer, at least for smokers.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0071899en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749214/pdf/en
dash.licenseLAAen_US
dc.subjectMedicineen
dc.subjectEpidemiologyen
dc.subjectEnvironmental Epidemiologyen
dc.subjectGastroenterology and Hepatologyen
dc.subjectGastrointestinal Cancersen
dc.subjectOncologyen
dc.subjectCancer Risk Factorsen
dc.subjectEnvironmental Causes of Canceren
dc.subjectCancers and Neoplasmsen
dc.subjectGastrointestinal Tumorsen
dc.subjectLung and Intrathoracic Tumorsen
dc.subjectCancer Preventionen
dc.subjectPulmonologyen
dc.subjectEnvironmental and Occupational Lung Diseasesen
dc.subjectAsbestosisen
dc.titleCancer Mortality in Chinese Chrysotile Asbestos Miners: Exposure-Response Relationshipsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorChristiani, David C.en_US
dc.date.available2014-03-01T02:23:57Z
dc.identifier.doi10.1371/journal.pone.0071899*
dash.contributor.affiliatedChristiani, David


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