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dc.contributor.authorvan Mulukom, Valerieen_US
dc.contributor.authorSchacter, Daniel L.en_US
dc.contributor.authorCorballis, Michael C.en_US
dc.contributor.authorAddis, Donna Roseen_US
dc.date.accessioned2014-03-01T02:24:28Z
dc.date.issued2013en_US
dc.identifier.citationvan Mulukom, Valerie, Daniel L. Schacter, Michael C. Corballis, and Donna Rose Addis. 2013. “Re-Imagining the Future: Repetition Decreases Hippocampal Involvement in Future Simulation.” PLoS ONE 8 (7): e69596. doi:10.1371/journal.pone.0069596. http://dx.doi.org/10.1371/journal.pone.0069596.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855779
dc.description.abstractImagining or simulating future events has been shown to activate the anterior right hippocampus (RHC) more than remembering past events does. One fundamental difference between simulation and memory is that imagining future scenarios requires a more extensive constructive process than remembering past experiences does. Indeed, studies in which this constructive element is reduced or eliminated by “pre-imagining” events in a prior session do not report differential RHC activity during simulation. In this fMRI study, we examined the effects of repeatedly simulating an event on neural activity. During scanning, participants imagined 60 future events; each event was simulated three times. Activation in the RHC showed a significant linear decrease across repetitions, as did other neural regions typically associated with simulation. Importantly, such decreases in activation could not be explained by non-specific linear time-dependent effects, with no reductions in activity evident for the control task across similar time intervals. Moreover, the anterior RHC exhibited significant functional connectivity with the whole-brain network during the first, but not second and third simulations of future events. There was also evidence of a linear increase in activity across repetitions in right ventral precuneus, right posterior cingulate and left anterior prefrontal cortex, which may reflect source recognition and retrieval of internally generated contextual details. Overall, our findings demonstrate that repeatedly imagining future events has a decremental effect on activation of the hippocampus and many other regions engaged by the initial construction of the simulation, possibly reflecting the decreasing novelty of simulations across repetitions, and therefore is an important consideration in the design of future studies examining simulation.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0069596en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720617/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectAnatomy and Physiologyen
dc.subjectNeurological Systemen
dc.subjectNeuroscienceen
dc.subjectNeuroimagingen
dc.subjectFmrien
dc.subjectNeurophysiologyen
dc.subjectCentral Nervous Systemen
dc.subjectCognitive Neuroscienceen
dc.subjectMedicineen
dc.subjectMental Healthen
dc.subjectPsychologyen
dc.subjectNeuropsychologyen
dc.subjectSocial and Behavioral Sciencesen
dc.subjectCognitive Psychologyen
dc.subjectMemoryen
dc.titleRe-Imagining the Future: Repetition Decreases Hippocampal Involvement in Future Simulationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorSchacter, Daniel L.en_US
dc.date.available2014-03-01T02:24:28Z
dc.identifier.doi10.1371/journal.pone.0069596*
dash.contributor.affiliatedSchacter, Daniel
dc.identifier.orcid0000-0002-2460-6061


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