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dc.contributor.authorBillings, Liana K.en_US
dc.contributor.authorHsu, Yi-Hsiangen_US
dc.contributor.authorAckerman, Rachel J.en_US
dc.contributor.authorDupuis, Joséeen_US
dc.contributor.authorVoight, Benjamin F.en_US
dc.contributor.authorRasmussen-Torvik, Laura J.en_US
dc.contributor.authorHercberg, Sergeen_US
dc.contributor.authorLathrop, Marken_US
dc.contributor.authorBarnes, Danielen_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorHui, Jennieen_US
dc.contributor.authorFu, Maoen_US
dc.contributor.authorBouatia-Naji, Nabilaen_US
dc.contributor.authorLecoeur, Cecileen_US
dc.contributor.authorAn, Pingen_US
dc.contributor.authorMagnusson, Patrik K.en_US
dc.contributor.authorSurakka, Idaen_US
dc.contributor.authorRipatti, Samulien_US
dc.contributor.authorChristiansen, Leneen_US
dc.contributor.authorDalgård, Christineen_US
dc.contributor.authorFolkersen, Lasseen_US
dc.contributor.authorGrundberg, Elinen_US
dc.contributor.authorEriksson, Peren_US
dc.contributor.authorKaprio, Jaakkoen_US
dc.contributor.authorOhm Kyvik, Kirstenen_US
dc.contributor.authorPedersen, Nancy L.en_US
dc.contributor.authorBorecki, Ingrid B.en_US
dc.contributor.authorProvince, Michael A.en_US
dc.contributor.authorBalkau, Beverleyen_US
dc.contributor.authorFroguel, Philippeen_US
dc.contributor.authorShuldiner, Alan R.en_US
dc.contributor.authorPalmer, Lyle J.en_US
dc.contributor.authorWareham, Nicken_US
dc.contributor.authorMeneton, Pierreen_US
dc.contributor.authorJohnson, Tobyen_US
dc.contributor.authorPankow, James S.en_US
dc.contributor.authorKarasik, Daviden_US
dc.contributor.authorMeigs, James B.en_US
dc.contributor.authorKiel, Douglas P.en_US
dc.contributor.authorFlorez, Jose C.en_US
dc.date.accessioned2014-03-01T02:24:37Z
dc.date.issued2012en_US
dc.identifier.citationBillings, L. K., Y. Hsu, R. J. Ackerman, J. Dupuis, B. F. Voight, L. J. Rasmussen-Torvik, S. Hercberg, et al. 2012. “Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits.” Diabetes 61 (8): 2176-2186. doi:10.2337/db11-1515. http://dx.doi.org/10.2337/db11-1515.en
dc.identifier.issn0012-1797en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855790
dc.description.abstractExploring genetic pleiotropy can provide clues to a mechanism underlying the observed epidemiological association between type 2 diabetes and heightened fracture risk. We examined genetic variants associated with bone mineral density (BMD) for association with type 2 diabetes and glycemic traits in large well-phenotyped and -genotyped consortia. We undertook follow-up analysis in ∼19,000 individuals and assessed gene expression. We queried single nucleotide polymorphisms (SNPs) associated with BMD at levels of genome-wide significance, variants in linkage disequilibrium (r2 > 0.5), and BMD candidate genes. SNP rs6867040, at the ITGA1 locus, was associated with a 0.0166 mmol/L (0.004) increase in fasting glucose per C allele in the combined analysis. Genetic variants in the ITGA1 locus were associated with its expression in the liver but not in adipose tissue. ITGA1 variants appeared among the top loci associated with type 2 diabetes, fasting insulin, β-cell function by homeostasis model assessment, and 2-h post–oral glucose tolerance test glucose and insulin levels. ITGA1 has demonstrated genetic pleiotropy in prior studies, and its suggested role in liver fibrosis, insulin secretion, and bone healing lends credence to its contribution to both osteoporosis and type 2 diabetes. These findings further underscore the link between skeletal and glucose metabolism and highlight a locus to direct future investigations.en
dc.language.isoen_USen
dc.publisherAmerican Diabetes Associationen
dc.relation.isversionofdoi:10.2337/db11-1515en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402303/pdf/en
dash.licenseLAAen_US
dc.titleImpact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traitsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetesen
dash.depositing.authorMeigs, James B.en_US
dc.date.available2014-03-01T02:24:37Z
dc.identifier.doi10.2337/db11-1515*
dash.authorsorderedfalse
dash.contributor.affiliatedFlorez, Jose
dash.contributor.affiliatedMeigs, James
dash.contributor.affiliatedKiel, Douglas


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