X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

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X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

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Title: X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Author: Yildirim, Eda; Sadreyev, Ruslan I.; Pinter, Stefan F.; Lee, Jeannie T.

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Citation: Yildirim, Eda, Ruslan I. Sadreyev, Stefan F. Pinter, and Jeannie T. Lee. 2013. “X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.” Nature structural & molecular biology 19 (1): 56-61. doi:10.1038/nsmb.2195. http://dx.doi.org/10.1038/nsmb.2195.
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Abstract: Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate mechanism, we perform allele-specific ChIP-seq for chromatin epitopes and analyze RNA-seq data. The hypertranscribed Xa demonstrates enrichment of active chromatin marks relative to autosomes. We derive predictive models for relationships among POL-II, active mark densities, and gene expression, and suggest that Xa upregulation involves increased transcription initiation and elongation. Enrichment of active marks on Xa does not scale proportionally with transcription output, a disparity explained by nonlinear quantitative dependencies among active histone marks, POL-II occupancy, and transcription. Significantly, the trend of nonlinear upregulation also occurs on autosomes. Thus, Xa upregulation involves combined increases of active histone marks and POL-II occupancy, without invoking X-specific dependencies between chromatin states and transcription.
Published Version: doi:10.1038/nsmb.2195
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732781/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11855794
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