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dc.contributor.authorRiedel, Christian G.en_US
dc.contributor.authorDowen, Robert H.en_US
dc.contributor.authorLourenco, Guinevere F.en_US
dc.contributor.authorKirienko, Natalia V.en_US
dc.contributor.authorHeimbucher, Thomasen_US
dc.contributor.authorWest, Jason A.en_US
dc.contributor.authorBowman, Sarah K.en_US
dc.contributor.authorKingston, Robert E.en_US
dc.contributor.authorDillin, Andrewen_US
dc.contributor.authorAsara, John M.en_US
dc.contributor.authorRuvkun, Garyen_US
dc.date.accessioned2014-03-01T02:25:06Z
dc.date.issued2013en_US
dc.identifier.citationRiedel, C. G., R. H. Dowen, G. F. Lourenco, N. V. Kirienko, T. Heimbucher, J. A. West, S. K. Bowman, et al. 2013. “DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.” Nature cell biology 15 (5): 491-501. doi:10.1038/ncb2720. http://dx.doi.org/10.1038/ncb2720.en
dc.identifier.issn1465-7392en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855858
dc.description.abstractOrganisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The transcription factor DAF-16/FOXO is central nexus in these responses, but despite its importance little is known about how it regulates its target genes. Proteomic identification of DAF-16/FOXO binding partners in Caenorhabditis elegans and their subsequent functional evaluation by RNA interference (RNAi) revealed several candidate DAF-16/FOXO cofactors, most notably the chromatin remodeller SWI/SNF. DAF-16/FOXO and SWI/SNF form a complex and globally colocalize at DAF-16/FOXO target promoters. We show that specifically for gene-activation, DAF-16/FOXO depends on SWI/SNF, facilitating SWI/SNF recruitment to target promoters, in order to activate transcription by presumed remodelling of local chromatin. For the animal, this translates into an essential role of SWI/SNF for DAF-16/FOXO-mediated processes, i.e. dauer formation, stress resistance, and the promotion of longevity. Thus we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncb2720en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748955/pdf/en
dash.licenseLAAen_US
dc.subjecten
dc.subjectFOXOen
dc.subjectSWI/SNFen
dc.subjectlongevityen
dc.subjectstress responseen
dc.subjectdauer formationen
dc.subjectchromatin remodellingen
dc.subjectproteomicsen
dc.titleDAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature cell biologyen
dash.depositing.authorDowen, Robert H.en_US
dc.date.available2014-03-01T02:25:06Z
dc.identifier.doi10.1038/ncb2720*
dash.authorsorderedfalse
dash.contributor.affiliatedBowman, Sarah K.
dash.contributor.affiliatedKirienko, Natalia
dash.contributor.affiliatedRuvkun, Gary
dash.contributor.affiliatedDowen, Robert H.
dash.contributor.affiliatedKingston, Robert
dash.contributor.affiliatedAsara, John


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