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dc.contributor.authorXia, Xiaojunen_US
dc.contributor.authorPark, Eunmien_US
dc.contributor.authorFischer, Susan M.en_US
dc.contributor.authorHu, Yinlingen_US
dc.date.accessioned2014-03-01T02:25:37Z
dc.date.issued2013en_US
dc.identifier.citationXia, Xiaojun, Eunmi Park, Susan M. Fischer, and Yinling Hu. 2013. “Mouse Genetic Models Reveal Surprising Functions of IκB Kinase Alpha in Skin Development and Skin Carcinogenesis.” Cancers 5 (1): 170-183. doi:10.3390/cancers5010170. http://dx.doi.org/10.3390/cancers5010170.en
dc.identifier.issn2072-6694en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855921
dc.description.abstractGene knockout studies unexpectedly reveal a pivotal role for IκB kinase alpha (IKKα) in mouse embryonic skin development. Skin carcinogenesis experiments show that Ikkα heterozygous mice are highly susceptible to chemical carcinogen or ultraviolet B light (UVB) induced benign and malignant skin tumors in comparison to wild-type mice. IKKα deletion mediated by keratin 5 (K5).Cre or K15.Cre in keratinocytes induces epidermal hyperplasia and spontaneous skin squamous cell carcinomas (SCCs) in Ikkα floxed mice. On the other hand, transgenic mice overexpressing IKKα in the epidermis, under the control of a truncated loricrin promoter or K5 promoter, develop normal skin and show no defects in the formation of the epidermis and other epithelial organs, and the transgenic IKKα represses chemical carcinogen or UVB induced skin carcinogenesis. Moreover, IKKα deletion mediated by a mutation, which generates a stop codon in the Ikkα gene, has been reported in a human autosomal recessive lethal syndrome. Downregulated IKKα and Ikkα mutations and deletions are found in human skin SCCs. The collective evidence not only highlights the importance of IKKα in skin development, maintaining skin homeostasis, and preventing skin carcinogenesis, but also demonstrates that mouse models are extremely valuable tools for revealing the mechanisms underlying these biological events, leading our studies from bench side to bedside.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/cancers5010170en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730312/pdf/en
dash.licenseLAAen_US
dc.subjectskin carcinogenesisen
dc.subjectskin developmenten
dc.subjectIKKalpha (IKKα)en
dc.titleMouse Genetic Models Reveal Surprising Functions of IκB Kinase Alpha in Skin Development and Skin Carcinogenesisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCancersen
dash.depositing.authorPark, Eunmien_US
dc.date.available2014-03-01T02:25:37Z
dc.identifier.doi10.3390/cancers5010170*
dash.contributor.affiliatedPark, Eunmi


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