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dc.contributor.authorPerez-Padilla, Rogelioen_US
dc.contributor.authorWehrmeister, Fernando C.en_US
dc.contributor.authorCelli, Bartolome R.en_US
dc.contributor.authorLopez-Varela, Maria Victorinaen_US
dc.contributor.authorMontes de Oca, Mariaen_US
dc.contributor.authorMuiño, Adrianaen_US
dc.contributor.authorTalamo, Carlosen_US
dc.contributor.authorJardim, Jose R.en_US
dc.contributor.authorValdivia, Gonzaloen_US
dc.contributor.authorLisboa, Carmenen_US
dc.contributor.authorMenezes, Ana Maria B.en_US
dc.date.accessioned2014-03-01T02:25:40Z
dc.date.issued2013en_US
dc.identifier.citationPerez-Padilla, R., F. C. Wehrmeister, B. R. Celli, M. V. Lopez-Varela, M. Montes de Oca, A. Muiño, C. Talamo, et al. 2013. “Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study.” PLoS ONE 8 (8): e67960. doi:10.1371/journal.pone.0067960. http://dx.doi.org/10.1371/journal.pone.0067960.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855928
dc.description.abstractQUESTION A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction. METHODS The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5–9 years in three Latin-American cities. RESULTS Using the FEV1/FVC<Lower limit of normal (LLN) index, COPD prevalence apparently changed from 9.8 to 13.2% in Montevideo, from 9.7 to 6.0% in São Paulo and from 8.5 to 6.6% in Santiago, despite only slight declines in smoking prevalence (from 30.8% to 24.3%). These changes were associated with differences in Forced expiratory time (FET) between the two surveys. In contrast, by using the FEV1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40). CONCLUSION The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV6<LLN helps to understand differences in prevalence of COPD obtained from FEV1/FVC-derived indices.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0067960en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731337/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectAnatomy and Physiologyen
dc.subjectRespiratory Systemen
dc.subjectRespiratory Physiologyen
dc.subjectPopulation Biologyen
dc.subjectEpidemiologyen
dc.subjectMedicineen
dc.subjectClinical Research Designen
dc.subjectDiagnostic Medicineen
dc.subjectTest Evaluationen
dc.subjectEpidemiological Methodsen
dc.subjectPulmonologyen
dc.subjectChronic Obstructive Pulmonary Diseasesen
dc.titleReliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorCelli, Bartolome R.en_US
dc.date.available2014-03-01T02:25:40Z
dc.identifier.doi10.1371/journal.pone.0067960*
dash.authorsorderedfalse
dash.contributor.affiliatedCelli, Bartolome


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