Robust, synergistic regulation of human gene expression using TALE activators

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Robust, synergistic regulation of human gene expression using TALE activators

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Title: Robust, synergistic regulation of human gene expression using TALE activators
Author: Maeder, Morgan L.; Linder, Samantha J.; Reyon, Deepak; Angstman, James F.; Fu, Yanfang; Sander, Jeffry D.; Joung, J. Keith

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Citation: Maeder, Morgan L., Samantha J. Linder, Deepak Reyon, James F. Angstman, Yanfang Fu, Jeffry D. Sander, and J. Keith Joung. 2013. “Robust, synergistic regulation of human gene expression using TALE activators.” Nature methods 10 (3): 243-245. doi:10.1038/nmeth.2366. http://dx.doi.org/10.1038/nmeth.2366.
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Abstract: Artificial transcription activator-like (TAL) effector-based activators (TALE activators) have broad utility but previous studies suggest that these monomeric proteins often possess low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy and guide design of novel monomeric TAL effector-based fusion proteins.
Published Version: doi:10.1038/nmeth.2366
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584229/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11876985
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