Robust, synergistic regulation of human gene expression using TALE activators
Maeder, Morgan L.
Joung, J. Keith
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CitationMaeder, Morgan L., Samantha J. Linder, Deepak Reyon, James F. Angstman, Yanfang Fu, Jeffry D. Sander, and J. Keith Joung. 2013. “Robust, synergistic regulation of human gene expression using TALE activators.” Nature methods 10 (3): 243-245. doi:10.1038/nmeth.2366. http://dx.doi.org/10.1038/nmeth.2366.
AbstractArtificial transcription activator-like (TAL) effector-based activators (TALE activators) have broad utility but previous studies suggest that these monomeric proteins often possess low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy and guide design of novel monomeric TAL effector-based fusion proteins.
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