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dc.contributor.authorRajpathak, Swapnil N.en_US
dc.contributor.authorHe, Meianen_US
dc.contributor.authorSun, Qien_US
dc.contributor.authorKaplan, Robert C.en_US
dc.contributor.authorMuzumdar, Radhikaen_US
dc.contributor.authorRohan, Thomas E.en_US
dc.contributor.authorGunter, Marc J.en_US
dc.contributor.authorPollak, Michaelen_US
dc.contributor.authorKim, Mimien_US
dc.contributor.authorPessin, Jeffrey E.en_US
dc.contributor.authorBeasley, Jeannetteen_US
dc.contributor.authorWylie-Rosett, Judithen_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorStrickler, Howard D.en_US
dc.date.accessioned2014-03-10T16:16:13Z
dc.date.issued2012en_US
dc.identifier.citationRajpathak, S. N., M. He, Q. Sun, R. C. Kaplan, R. Muzumdar, T. E. Rohan, M. J. Gunter, et al. 2012. “Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women.” Diabetes 61 (9): 2248-2254. doi:10.2337/db11-1488. http://dx.doi.org/10.2337/db11-1488.en
dc.identifier.issn0012-1797en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11876990
dc.description.abstractIGF-I shares structural homology and in vitro metabolic activity with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case subjects matched 1:1 to control subjects) and its associations with IGF-axis protein levels in the Nurses’ Health Study, a cohort of middle-aged women. The median time to diabetes was 9 years. Statistical analyses were adjusted for multiple risk factors, including insulin and C-reactive protein. Diabetes risk was fivefold lower among women with baseline IGFBP-2 levels in the top versus bottom quintile (odds ratio [OR]q5–q1 = 0.17 [95% CI 0.08–0.35]; P trend < 0.0001) and was also negatively associated with IGFBP-1 levels (ORq5–q1 = 0.37 [0.18–0.73]; P trend = 0.0009). IGFBP-3 was positively associated with diabetes (ORq5–q1 = 2.05 [1.20–3.51]; P trend = 0.002). Diabetes was not associated with total IGF-I levels, but free IGF-I and diabetes had a significant association that varied (P interaction = 0.003) by insulin levels above the median (ORq5–q1 = 0.48 [0.26–0.90]; P trend = 0.0001) versus below the median (ORq5–q1 = 2.52 [1.05–6.06]; P trend < 0.05). Thus, this prospective study found strong associations of incident diabetes with baseline levels of three IGFBPs and free IGF-I, consistent with hypotheses that the IGF axis might influence diabetes risk.en
dc.language.isoen_USen
dc.publisherAmerican Diabetes Associationen
dc.relation.isversionofdoi:10.2337/db11-1488en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425426/pdf/en
dash.licenseLAAen_US
dc.titleInsulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Womenen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetesen
dash.depositing.authorSun, Qien_US
dc.date.available2014-03-10T16:16:13Z
dc.identifier.doi10.2337/db11-1488*
dash.authorsorderedfalse
dash.contributor.affiliatedSun, Qi
dash.contributor.affiliatedHu, Frank


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