dc.contributor.author | Leviton, Alan | en_US |
dc.contributor.author | Fichorova, Raina N. | en_US |
dc.contributor.author | O’Shea, T. Michael | en_US |
dc.contributor.author | Kuban, Karl | en_US |
dc.contributor.author | Paneth, Nigel | en_US |
dc.contributor.author | Dammann, Olaf | en_US |
dc.contributor.author | Allred, Elizabeth N. | en_US |
dc.date.accessioned | 2014-03-10T16:16:18Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Leviton, Alan, Raina N. Fichorova, T. Michael O’Shea, Karl Kuban, Nigel Paneth, Olaf Dammann, and Elizabeth N. Allred. 2013. “Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation.” Pediatric research 73 (3): 362-370. doi:10.1038/pr.2012.188. http://dx.doi.org/10.1038/pr.2012.188. | en |
dc.identifier.issn | 0031-3998 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11876998 | |
dc.description.abstract | Background: We sought to disentangle the contributions of perinatal systemic inflammation and small for gestational age (SGA) to the occurrence of low Bayley Mental Development Indices (MDIs) at age 2 years. Method We measured the concentration of 25 inflammation-related proteins in blood obtained during the first 2 postnatal weeks from 805 infants who were born before the 28th week of gestation and who had MDI measurements at age 2 years and were able to walk independently. Results: SGA newborns who did not have systemic inflammation (a concentration of an inflammation-related protein in the top quartile for gestational age on 2 days a week apart) were at greater risk of an MDI < 55, but not 55–69, than their peers who had neither SGA nor systemic inflammation. SGA infants who had elevated blood concentrations of IL-1beta, TNF-alpha, or IL-8 during the first two postnatal weeks were at even higher risk of an MDI < 55 than their SGA peers without systemic inflammation and of their non-SGA peers with systemic inflammation. Conclusion: SGA appears to place very preterm newborns at increased risk of a very low MDI. Systemic inflammation adds considerably to the increased risk. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/pr.2012.188 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642985/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Pediatric research | en |
dash.depositing.author | Leviton, Alan | en_US |
dc.date.available | 2014-03-10T16:16:18Z | |
dc.identifier.doi | 10.1038/pr.2012.188 | * |
dash.contributor.affiliated | Allred, Elizabeth | |
dash.contributor.affiliated | Fichorova, Raina | |
dash.contributor.affiliated | Leviton, Alan | |