Show simple item record

dc.contributor.authorMendivil, Carlos O.en_US
dc.contributor.authorRimm, Eric B.en_US
dc.contributor.authorFurtado, Jeremyen_US
dc.contributor.authorSacks, Frank M.en_US
dc.date.accessioned2014-03-10T16:16:21Z
dc.date.issued2013en_US
dc.identifier.citationMendivil, Carlos O., Eric B. Rimm, Jeremy Furtado, and Frank M. Sacks. 2013. “Apolipoprotein E in VLDL and LDL With Apolipoprotein C‐III is Associated With a Lower Risk of Coronary Heart Disease.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2 (3): e000130. doi:10.1161/JAHA.113.000130. http://dx.doi.org/10.1161/JAHA.113.000130.en
dc.identifier.issn2047-9980en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11877004
dc.description.abstractBackground: Low‐density lipoprotein (LDL) with apolipoprotein C‐III (apoC‐III) is the lipoprotein species that most strongly predicts initial and recurring coronary heart disease (CHD) events in several cohorts. Thus, a large portion of the CHD risk conferred by LDL may be attributable to LDL that contains apoC‐III. Very‐low‐density lipoprotein (VLDL) and LDL with apoC‐III have varying amounts of apoE. We hypothesized that a high content of apoE lessens the adverse influence of apoC‐III on the risk of CHD because it promotes the clearance of VLDL and LDL from plasma. Methods and Results: We studied 2 independent cohorts, the Nurses' Health Study, composed of women, and the Health Professionals Follow‐up Study, composed of men. These cohorts contributed to this study 322 women and 418 men initially free of CVD who developed a fatal or nonfatal myocardial infarction during 10 to 14 years of follow‐up and matched controls who remained free of CHD. The apoE content of LDL with apoC‐III was inversely associated with CHD after multivariable adjustment (relative risk for top versus bottom quintile 0.53, 95% CI 0.35 to 0.80). The apoE content of VLDL with apoC‐III had a similar inverse association with CHD. The highest risks were associated with a high apoB concentration and a low apoE content of LDL with apoC‐III or of VLDL+LDL with apoC‐III. The observed associations were in both male and female cohorts and independent of traditional CHD risk factors and of C‐reactive protein. Conclusions: An increased apoE content in VLDL and LDL with apoC‐III was associated with a lower risk of CHD. Strategies to enrich VLDL and LDL in apoE are worth exploring for the prevention of CHD.en
dc.language.isoen_USen
dc.publisherBlackwell Publishing Ltden
dc.relation.isversionofdoi:10.1161/JAHA.113.000130en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698772/pdf/en
dash.licenseLAAen_US
dc.subjectCoronary Heart Diseaseen
dc.subjectapolipoproteinen
dc.subjectcholesterolen
dc.subjectcoronary diseaseen
dc.subjectlipoproteinsen
dc.subjectrisk factoren
dc.titleApolipoprotein E in VLDL and LDL With Apolipoprotein C‐III is Associated With a Lower Risk of Coronary Heart Diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseaseen
dash.depositing.authorRimm, Eric B.en_US
dc.date.available2014-03-10T16:16:21Z
dc.identifier.doi10.1161/JAHA.113.000130*
dash.contributor.affiliatedRimm, Eric
dash.contributor.affiliatedFurtado, Jeremy
dash.contributor.affiliatedSacks, Frank


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record