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dc.contributor.authorWilker, Elissa H.en_US
dc.contributor.authorMittleman, Murray A.en_US
dc.contributor.authorCoull, Brent A.en_US
dc.contributor.authorGryparis, Alexandrosen_US
dc.contributor.authorBots, Michiel L.en_US
dc.contributor.authorSchwartz, Joelen_US
dc.contributor.authorSparrow, Daviden_US
dc.date.accessioned2014-03-10T16:16:27Z
dc.date.issued2013en_US
dc.identifier.citationWilker, Elissa H., Murray A. Mittleman, Brent A. Coull, Alexandros Gryparis, Michiel L. Bots, Joel Schwartz, and David Sparrow. 2013. “Long-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Study.” Environmental Health Perspectives 121 (9): 1061-1067. doi:10.1289/ehp.1104845. http://dx.doi.org/10.1289/ehp.1104845.en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11877015
dc.description.abstractBackground: Evidence suggests that air pollution is associated with atherosclerosis and that traffic-related particles are a particularly important contributor to the association. Objectives: We investigated the association between long-term exposure to black carbon, a correlate of traffic particles, and intima-media thickness of the common carotid artery (CIMT) in elderly men residing in the greater Boston, Massachusetts, area. Methods: We estimated 1-year average exposures to black carbon at the home addresses of Normative Aging Study participants before their first CIMT measurement. The association between estimated black carbon levels and CIMT was estimated using mixed effects models to account for repeated outcome measures. In secondary analyses, we examined whether living close to a major road or average daily traffic within 100 m of residence was associated with CIMT. Results: There were 380 participants (97% self-reported white race) with an initial visit between 2004 and 2008. Two or three follow-up CIMT measurements 1.5 years apart were available for 340 (89%) and 260 (68%) men, respectively. At first examination, the average ± SD age was 76 ± 6.4 years and the mean ± SD CIMT was 0.99 ± 0.18 mm. A one-interquartile range increase in 1-year average black carbon (0.26 µg/m3) was associated with a 1.1% higher CIMT (95% CI: 0.4, 1.7%) based on a fully adjusted model. Conclusions: Annual mean black carbon concentration based on spatially resolved exposure estimates was associated with CIMT in a population of elderly men. These findings support an association between long-term air pollution exposure and atherosclerosis. Citation: Wilker EH, Mittleman MA, Coull BA, Gryparis A, Bots ML, Schwartz J, Sparrow D. 2013. Long-term exposure to black carbon and carotid intima-media thickness: the Normative Aging Study. Environ Health Perspect 121:1061–1067; http://dx.doi.org/10.1289/ehp.1104845 [Online 2 July 2013]en
dc.language.isoen_USen
dc.publisherNational Institute of Environmental Health Sciencesen
dc.relation.isversionofdoi:10.1289/ehp.1104845en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764069/pdf/en
dash.licenseLAAen_US
dc.titleLong-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Health Perspectivesen
dash.depositing.authorWilker, Elissa H.en_US
dc.date.available2014-03-10T16:16:27Z
dc.identifier.doi10.1289/ehp.1104845*
dash.contributor.affiliatedWilker, Elissa
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedCoull, Brent


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