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dc.contributor.authorFrank, David A.en_US
dc.date.accessioned2014-03-10T16:17:24Z
dc.date.issued2012en_US
dc.identifier.citationFrank, David A. 2012. “Targeting STATs for cancer therapy: “Undruggable” no more.” JAK-STAT 1 (4): 261-262. doi:10.4161/jkst.22528. http://dx.doi.org/10.4161/jkst.22528.en
dc.identifier.issn2162-3988en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11877090
dc.description.abstractWe are in the midst of an exciting transition in the treatment of cancers, from the empirically developed non-specifically cytotoxic drugs to the era of rationally derived molecularly targeted therapies. Over the past 15 years, our understanding of the mutations that drive cancer pathogenesis has grown enormously, which has rapidly led to the development of drugs to target the associated gene products. Almost all of this focus has been on kinases, largely tyrosine kinases that are activated by translocations, point mutations, insertions and deletions. Although this approach will continue to bear fruit for some time, there is increasing evidence that the returns will be diminishing. First, dominant activating mutations in kinases are less frequent then initially expected particularly in common human cancers, and thus the number of patient whose tumors have suitable targets may be limited. The second cause for concern is the rapid development of resistance that often occurs, arising either from mutations in the target kinase or activation of a parallel pathway. Thus, the desire to target a common convergence point of multiple pathways that directly contributes to the oncogenic phenotype is highly desirable. This goal has led to consideration of transcription factors as therapeutic targets.en
dc.language.isoen_USen
dc.publisherLandes Bioscienceen
dc.relation.isversionofdoi:10.4161/jkst.22528en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670283/pdf/en
dash.licenseLAAen_US
dc.titleTargeting STATs for cancer therapy: “Undruggable” no moreen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJAK-STATen
dash.depositing.authorFrank, David A.en_US
dc.date.available2014-03-10T16:17:24Z
dc.identifier.doi10.4161/jkst.22528*
dash.contributor.affiliatedFrank, David


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