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dc.contributor.authorKulkarni, Rohit N.en_US
dc.contributor.authorMizrachi, Ernesto-Bernalen_US
dc.contributor.authorOcana, Adolfo Garciaen_US
dc.contributor.authorStewart, Andrew F.en_US
dc.date.accessioned2014-03-10T16:17:24Z
dc.date.issued2012en_US
dc.identifier.citationKulkarni, Rohit N., Ernesto-Bernal Mizrachi, Adolfo Garcia Ocana, and Andrew F. Stewart. 2012. “Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map.” Diabetes 61 (9): 2205-2213. doi:10.2337/db12-0018. http://dx.doi.org/10.2337/db12-0018.en
dc.identifier.issn0012-1797en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11877092
dc.description.abstractA major goal in diabetes research is to find ways to enhance the mass and function of insulin secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even reverse overt diabetes. In this Perspectives in Diabetes article, we highlight the contrast between the relatively large body of information that is available in regard to signaling pathways, proteins, and mechanisms that together provide a road map for efforts to regenerate β-cells in rodents versus the scant information in human β-cells. To reverse the state of ignorance regarding human β-cell signaling, we suggest a series of questions for consideration by the scientific community to construct a human β-cell proliferation road map. The hope is that the knowledge from the new studies will allow the community to move faster towards developing therapeutic approaches to enhance human β-cell mass in the long-term goal of preventing and/or curing type 1 and type 2 diabetes.en
dc.language.isoen_USen
dc.publisherAmerican Diabetes Associationen
dc.relation.isversionofdoi:10.2337/db12-0018en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425429/pdf/en
dash.licenseLAAen_US
dc.titleHuman β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Mapen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetesen
dash.depositing.authorKulkarni, Rohit N.en_US
dc.date.available2014-03-10T16:17:24Z
dc.identifier.doi10.2337/db12-0018*
dash.contributor.affiliatedKulkarni, Rohit


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