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dc.contributor.authorLiu, Yingen_US
dc.contributor.authorColditz, Graham A.en_US
dc.contributor.authorRosner, Bernarden_US
dc.contributor.authorBerkey, Catherine S.en_US
dc.contributor.authorCollins, Laura C.en_US
dc.contributor.authorSchnitt, Stuart J.en_US
dc.contributor.authorConnolly, James L.en_US
dc.contributor.authorChen, Wendy Y.en_US
dc.contributor.authorWillett, Walter C.en_US
dc.contributor.authorTamimi, Rulla M.en_US
dc.date.accessioned2014-03-10T20:33:03Z
dc.date.issued2013en_US
dc.identifier.citationLiu, Ying, Graham A. Colditz, Bernard Rosner, Catherine S. Berkey, Laura C. Collins, Stuart J. Schnitt, James L. Connolly, Wendy Y. Chen, Walter C. Willett, and Rulla M. Tamimi. 2013. “Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk.” JNCI Journal of the National Cancer Institute 105 (20): 1571-1578. doi:10.1093/jnci/djt213. http://dx.doi.org/10.1093/jnci/djt213.en
dc.identifier.issn0027-8874en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11878834
dc.description.abstractBackground: Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer. Methods: We used data from 91005 parous women in the Nurses’ Health Study II who had no cancer history, completed questions on early alcohol consumption in 1989, and were followed through June 30, 2009, to analyze breast cancer risk. A subset of 60093 women who had no history of BBD or cancer in 1991 and were followed through June 30, 2001, were included in the analysis of proliferative BBD. Relative risks (RRs) were estimated using Cox proportional hazard regression. Results: We identified 1609 breast cancer cases and 970 proliferative BBD cases confirmed by central histology review. Alcohol consumption between menarche and first pregnancy, adjusted for drinking after first pregnancy, was associated with risks of breast cancer (RR = 1.11 per 10g/day intake; 95% confidence interval [CI] = 1.00 to 1.23) and proliferative BBD (RR = 1.16 per 10g/day intake; 95% CI = 1.02 to 1.32). Drinking after first pregnancy had a similar risk for breast cancer (RR = 1.09 per 10g/day intake; 95% CI = 0.96 to 1.23) but not for BBD. The association between drinking before first pregnancy and breast neoplasia appeared to be stronger with longer menarche to first pregnancy intervals. Conclusions: Alcohol consumption before first pregnancy was consistently associated with increased risks of proliferative BBD and breast cancer.en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.relation.isversionofdoi:10.1093/jnci/djt213en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797023/pdf/en
dash.licenseLAAen_US
dc.titleAlcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risken
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJNCI Journal of the National Cancer Instituteen
dash.depositing.authorLiu, Yingen_US
dc.date.available2014-03-10T20:33:03Z
dc.identifier.doi10.1093/jnci/djt213*
dash.contributor.affiliatedBerkey, Catherine
dash.contributor.affiliatedLiu, Ying
dash.contributor.affiliatedChen, Wendy
dash.contributor.affiliatedConnolly, James
dash.contributor.affiliatedCollins, Laura
dash.contributor.affiliatedColditz, Graham
dash.contributor.affiliatedSchnitt, Stuart
dash.contributor.affiliatedTamimi, Rulla
dash.contributor.affiliatedWillett, Walter
dash.contributor.affiliatedRosner, Bernard


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