Show simple item record

dc.contributor.authorLi, Yanen_US
dc.contributor.authorSacchi, Silviaen_US
dc.contributor.authorPollegioni, Loredanoen_US
dc.contributor.authorBasu, Alo C.en_US
dc.contributor.authorCoyle, Joseph T.en_US
dc.contributor.authorBolshakov, Vadim Y.en_US
dc.date.accessioned2014-03-10T20:34:02Z
dc.date.issued2013en_US
dc.identifier.citationLi, Yan, Silvia Sacchi, Loredano Pollegioni, Alo C. Basu, Joseph T. Coyle, and Vadim Y. Bolshakov. 2013. “Identity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Level.” Nature communications 4 (1): 1760. doi:10.1038/ncomms2779. http://dx.doi.org/10.1038/ncomms2779.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11878909
dc.description.abstractMechanisms of NMDA receptor-dependent synaptic plasticity contribute to the acquisition and retention of conditioned fear memory. However, synaptic rules which may determine the extent of NMDA receptor activation in the amygdala, a key structure implicated in fear learning, remain unknown. Here we show that the identity of the NMDAR glycine site agonist at synapses in the lateral nucleus of the amygdala may depend on the level of synaptic activation. Tonic activation of NMDARs at synapses in the amygdala under low-activity conditions is supported by ambient D-serine, whereas glycine may be released from astrocytes in response to afferent impulses. The release of glycine may decode the increases in afferent activity levels into enhanced NMDAR-mediated synaptic events, serving an essential function in the induction of NMDAR-dependent long-term potentiation in fear conditioning pathways.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncomms2779en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641574/pdf/en
dash.licenseLAAen_US
dc.titleIdentity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Levelen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature communicationsen
dash.depositing.authorLi, Yanen_US
dc.date.available2014-03-10T20:34:02Z
dc.identifier.doi10.1038/ncomms2779*
dash.contributor.affiliatedLi, Yan
dash.contributor.affiliatedBolshakov, Vadim
dash.contributor.affiliatedCoyle, Joseph


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record