dc.contributor.author | Ye, Min | en_US |
dc.contributor.author | Zhang, Hong | en_US |
dc.contributor.author | Amabile, Giovanni | en_US |
dc.contributor.author | Yang, Henry | en_US |
dc.contributor.author | Staber, Philipp B. | en_US |
dc.contributor.author | Zhang, Pu | en_US |
dc.contributor.author | Levantini, Elena | en_US |
dc.contributor.author | Alberich-Jordà, Meritxell | en_US |
dc.contributor.author | Zhang, Junyan | en_US |
dc.contributor.author | Kawasaki, Akira | en_US |
dc.contributor.author | Tenen, Daniel G. | en_US |
dc.date.accessioned | 2014-03-10T20:34:18Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Ye, M., H. Zhang, G. Amabile, H. Yang, P. B. Staber, P. Zhang, E. Levantini, et al. 2013. “C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence.” Nature cell biology 15 (4): 385-394. doi:10.1038/ncb2698. http://dx.doi.org/10.1038/ncb2698. | en |
dc.identifier.issn | 1465-7392 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11878939 | |
dc.description.abstract | Summary In blood, transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver (FL) hematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here, using an inducible knockout model we found that C/EBPa deficient adult HSCs underwent a pronounced expansion with enhanced proliferation, characteristics resembling FL HSCs. Consistently, transcription profiling of C/EBPa deficient HSCs revealed a gene expression programme similar to FL HSCs. Moreover we observed that age-specific C/EBPa expression correlated with its inhibitory effect on HSC cell cycle. Mechanistically we identified N-Myc as C/EBPa downstream target, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ncb2698 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781213/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Transcription factor | en |
dc.subject | C/EBPa | en |
dc.subject | hematopoietic stem cell | en |
dc.subject | quiescence | en |
dc.subject | proliferation | en |
dc.subject | N-Myc | en |
dc.title | C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature cell biology | en |
dash.depositing.author | Zhang, Hong | en_US |
dc.date.available | 2014-03-10T20:34:18Z | |
dc.identifier.doi | 10.1038/ncb2698 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Staber, Philipp B. | |
dash.contributor.affiliated | Zhang, Pu | |
dash.contributor.affiliated | Zhang, Hong | |
dash.contributor.affiliated | Levantini, Elena | |
dash.contributor.affiliated | Tenen, Daniel | |