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dc.contributor.authorYe, Minen_US
dc.contributor.authorZhang, Hongen_US
dc.contributor.authorAmabile, Giovannien_US
dc.contributor.authorYang, Henryen_US
dc.contributor.authorStaber, Philipp B.en_US
dc.contributor.authorZhang, Puen_US
dc.contributor.authorLevantini, Elenaen_US
dc.contributor.authorAlberich-Jordà, Meritxellen_US
dc.contributor.authorZhang, Junyanen_US
dc.contributor.authorKawasaki, Akiraen_US
dc.contributor.authorTenen, Daniel G.en_US
dc.date.accessioned2014-03-10T20:34:18Z
dc.date.issued2013en_US
dc.identifier.citationYe, M., H. Zhang, G. Amabile, H. Yang, P. B. Staber, P. Zhang, E. Levantini, et al. 2013. “C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence.” Nature cell biology 15 (4): 385-394. doi:10.1038/ncb2698. http://dx.doi.org/10.1038/ncb2698.en
dc.identifier.issn1465-7392en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11878939
dc.description.abstractSummary In blood, transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver (FL) hematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here, using an inducible knockout model we found that C/EBPa deficient adult HSCs underwent a pronounced expansion with enhanced proliferation, characteristics resembling FL HSCs. Consistently, transcription profiling of C/EBPa deficient HSCs revealed a gene expression programme similar to FL HSCs. Moreover we observed that age-specific C/EBPa expression correlated with its inhibitory effect on HSC cell cycle. Mechanistically we identified N-Myc as C/EBPa downstream target, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncb2698en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781213/pdf/en
dash.licenseLAAen_US
dc.subjectTranscription factoren
dc.subjectC/EBPaen
dc.subjecthematopoietic stem cellen
dc.subjectquiescenceen
dc.subjectproliferationen
dc.subjectN-Mycen
dc.titleC/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescenceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature cell biologyen
dash.depositing.authorZhang, Hongen_US
dc.date.available2014-03-10T20:34:18Z
dc.identifier.doi10.1038/ncb2698*
dash.authorsorderedfalse
dash.contributor.affiliatedStaber, Philipp B.
dash.contributor.affiliatedZhang, Pu
dash.contributor.affiliatedZhang, Hong
dash.contributor.affiliatedLevantini, Elena
dash.contributor.affiliatedTenen, Daniel


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