The dorsomedial striatum encodes net expected return, critical for energizing performance vigor

DSpace/Manakin Repository

The dorsomedial striatum encodes net expected return, critical for energizing performance vigor

Citable link to this page

 

 
Title: The dorsomedial striatum encodes net expected return, critical for energizing performance vigor
Author: Wang, Alice Y.; Miura, Keiji; Uchida, Naoshige

Note: Order does not necessarily reflect citation order of authors.

Citation: Wang, Alice Y., Keiji Miura, and Naoshige Uchida. 2013. “The dorsomedial striatum encodes net expected return, critical for energizing performance vigor.” Nature neuroscience 16 (5): 10.1038/nn.3377. doi:10.1038/nn.3377. http://dx.doi.org/10.1038/nn.3377.
Full Text & Related Files:
Abstract: Decision making requires an actor to not only steer behavior towards specific goals, but also determine the optimal vigor of performance. Current research and models have largely focused on the former problem of how actions are directed, while overlooking the latter problem of how they are energized. Here, we designed a self-paced decision-making paradigm that showed that rats' performance vigor globally fluctuates with the net value of their options, suggesting that they maintain long-term estimates of the value of their current state. Lesions of the dorsomedial (DMS), and to a lesser degree, in the ventral striatum (VS) impaired such state-dependent modulation of vigor, rendering vigor to depend more exclusively on the outcomes of immediately preceding trials. The lesions, however, spared choice biases. Neuronal recordings showed that the DMS is enriched with net-value-coding neurons. In sum, the DMS encodes one's net expected return, which drives the general motivation to perform.
Published Version: doi:10.1038/nn.3377
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651899/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11878977
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters