Myocardial Tissue Remodeling in Adolescent Obesity
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Author
Hulten, Edward
Coelho‐Filho, Otavio
Hoppin, Alison
Levitsky, Lynne
de Ferranti, Sarah
Rhodes, Erinn T.
Traum, Avram
Goodman, Elizabeth
Feng, Henry
Harris, William S.
Hoefner, Daniel M.
McConnell, Joseph P.
Seethamraju, Ravi
Rickers, Carsten
Jerosch‐Herold, Michael
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1161/JAHA.113.000279Metadata
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Shah, R. V., S. A. Abbasi, T. G. Neilan, E. Hulten, O. Coelho‐Filho, A. Hoppin, L. Levitsky, et al. 2013. “Myocardial Tissue Remodeling in Adolescent Obesity.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2 (4): e000279. doi:10.1161/JAHA.113.000279. http://dx.doi.org/10.1161/JAHA.113.000279.Abstract
Background: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. Methods and Results: We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m2, including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m2) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size‐adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high‐sensitivity C‐reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. Conclusions: Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828806/pdf/Terms of Use
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