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dc.contributor.authorMorgan, Claire Cen_US
dc.contributor.authorMc Cartney, Ann Men_US
dc.contributor.authorDonoghue, Mark TAen_US
dc.contributor.authorLoughran, Noeleen Ben_US
dc.contributor.authorSpillane, Charlesen_US
dc.contributor.authorTeeling, Emma Cen_US
dc.contributor.authorO’Connell, Mary Jen_US
dc.date.accessioned2014-03-11T02:48:36Z
dc.date.issued2013en_US
dc.identifier.citationMorgan, Claire C, Ann M Mc Cartney, Mark TA Donoghue, Noeleen B Loughran, Charles Spillane, Emma C Teeling, and Mary J O’Connell. 2013. “Molecular adaptation of telomere associated genes in mammals.” BMC Evolutionary Biology 13 (1): 251. doi:10.1186/1471-2148-13-251. http://dx.doi.org/10.1186/1471-2148-13-251.en
dc.identifier.issn1471-2148en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879043
dc.description.abstractBackground: Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of general trends have been proposed between these traits, there are exceptions that warrant further investigation. Species such as naked mole rat, human and certain bat species all exhibit extreme longevity with respect to body size. It has long been established that telomeres and telomere maintenance have a clear role in ageing but it has not yet been established whether there is evidence for adaptation in telomere maintenance proteins that could account for increased longevity in these species. Results: Here we carry out a molecular investigation of selective pressure variation, specifically focusing on telomere associated genes across placental mammals. In general we observe a large number of instances of positive selection acting on telomere genes. Although these signatures of selection overall are not significantly correlated with either longevity or body size we do identify positive selection in the microbat species Myotis lucifugus in functionally important regions of the telomere maintenance genes DKC1 and TERT, and in naked mole rat in the DNA repair gene BRCA1. Conclusion: These results demonstrate the multifarious selective pressures acting across the mammal phylogeny driving lineage-specific adaptations of telomere associated genes. Our results show that regardless of the longevity of a species, these proteins have evolved under positive selection thereby removing increased longevity as the single selective force driving this rapid rate of evolution. However, evidence of molecular adaptations specific to naked mole rat and Myotis lucifugus highlight functionally significant regions in genes that may alter the way in which telomeres are regulated and maintained in these longer-lived species.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1471-2148-13-251en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833184/pdf/en
dash.licenseLAAen_US
dc.subjectPositive selectionen
dc.subjectMammal molecular evolutionen
dc.subjectTelomereen
dc.subjectSenescenceen
dc.subjectLongevityen
dc.titleMolecular adaptation of telomere associated genes in mammalsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Evolutionary Biologyen
dc.date.available2014-03-11T02:48:36Z
dc.identifier.doi10.1186/1471-2148-13-251*


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