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dc.contributor.authorZirin, Jonathanen_US
dc.contributor.authorNieuwenhuis, Joppeen_US
dc.contributor.authorPerrimon, Norberten_US
dc.date.accessioned2014-03-11T02:49:01Z
dc.date.issued2013en_US
dc.identifier.citationZirin, Jonathan, Joppe Nieuwenhuis, and Norbert Perrimon. 2013. “Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy.” PLoS Biology 11 (11): e1001708. doi:10.1371/journal.pbio.1001708. http://dx.doi.org/10.1371/journal.pbio.1001708.en
dc.identifier.issn1544-9173en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879082
dc.description.abstractSeveral myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells. We have established a Drosophila melanogaster model to study glycogen autophagy in skeletal muscles, using chloroquine (CQ) to simulate a vacuolar myopathy that is completely dependent on the core autophagy genes. We show that autophagy is required for the most efficient degradation of glycogen in response to starvation. Furthermore, we show that CQ-induced myopathy can be improved by reduction of either autophagy or glycogen synthesis, the latter possibly due to a direct role of Glycogen Synthase in regulating autophagy through its interaction with Atg8.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pbio.1001708en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825659/pdf/en
dash.licenseLAAen_US
dc.titleRole of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Biologyen
dash.depositing.authorZirin, Jonathanen_US
dc.date.available2014-03-11T02:49:01Z
dc.identifier.doi10.1371/journal.pbio.1001708*
dash.contributor.affiliatedZirin, Jonathan
dash.contributor.affiliatedPerrimon, Norbert


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