Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction

DSpace/Manakin Repository

Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction

Citable link to this page

 

 
Title: Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
Author: Zarrinpashneh, Elham; Poggioli, Tommaso; Sarathchandra, Padmini; Lexow, Jonas; Monassier, Laurent; Terracciano, Cesare; Lang, Florian; Damilano, Federico; Zhou, Jessica Q.; Rosenzweig, Anthony; Rosenthal, Nadia; Santini, Maria Paola

Note: Order does not necessarily reflect citation order of authors.

Citation: Zarrinpashneh, E., T. Poggioli, P. Sarathchandra, J. Lexow, L. Monassier, C. Terracciano, F. Lang, et al. 2013. “Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction.” PLoS ONE 8 (11): e80268. doi:10.1371/journal.pone.0080268. http://dx.doi.org/10.1371/journal.pone.0080268.
Full Text & Related Files:
Abstract: Serum and glucocorticoid inducible kinase 1 (SGK1) plays a pivotal role in early angiogenesis during embryonic development. In this study, we sought to define the SGK1 downstream signalling pathways in the adult heart and to elucidate their role in cardiac neo-angiogenesis and wound healing after myocardial ischemia. To this end, we employed a viable SGK1 knockout mouse model generated in a 129/SvJ background. Ablation of SGK1 in these mice caused a significant decrease in phosphorylation of SGK1 target protein NDRG1, which correlated with alterations in NF-κB signalling and expression of its downstream target protein, VEGF-A. Disruption of these signalling pathways was accompanied by smaller heart and body size. Moreover, the lack of SGK1 led to defective endothelial cell (ECs) migration and tube formation in vitro, and increased scarring with decreased angiogenesis in vivo after myocardial infarct. This study underscores the importance of SGK1 signalling in cardiac neo-angiogenesis and wound healing after an ischemic insult in vivo.
Published Version: doi:10.1371/journal.pone.0080268
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827188/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879092
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters