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dc.contributor.authorKim, Eunhaen_US
dc.contributor.authorYang, Katherine S.en_US
dc.contributor.authorWeissleder, Ralphen_US
dc.date.accessioned2014-03-11T02:49:06Z
dc.date.issued2013en_US
dc.identifier.citationKim, Eunha, Katherine S. Yang, and Ralph Weissleder. 2013. “Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET.” PLoS ONE 8 (11): e81275. doi:10.1371/journal.pone.0081275. http://dx.doi.org/10.1371/journal.pone.0081275.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879093
dc.description.abstractThe hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical development. However, to date, it has been difficult to visualize MET expression, intracellular drug distribution and small molecule MET inhibition. Using a bioorthogonal approach, we have developed two companion imaging drugs based on both mono- and polypharmacological MET inhibitors. We show exquisite drug and target co-localization that can be visualized at single-cell resolution. The developed agents may be useful chemical biology tools to investigate single-cell pharmacokinetics and pharmacodynamics of MET inhibitors.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0081275en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827223/pdf/en
dash.licenseLAAen_US
dc.titleBioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of METen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorKim, Eunhaen_US
dc.date.available2014-03-11T02:49:06Z
dc.identifier.doi10.1371/journal.pone.0081275*
dash.contributor.affiliatedKim, Eunha
dash.contributor.affiliatedYang, Katherine
dash.contributor.affiliatedWeissleder, Ralph


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