Analysis of Morphological Parameters to Differentiate Rupture Status in Anterior Communicating Artery Aneurysms

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Analysis of Morphological Parameters to Differentiate Rupture Status in Anterior Communicating Artery Aneurysms

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Title: Analysis of Morphological Parameters to Differentiate Rupture Status in Anterior Communicating Artery Aneurysms
Author: Lin, Ning; Ho, Allen; Charoenvimolphan, Nareerat; Frerichs, Kai U.; Day, Arthur L.; Du, Rose

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Citation: Lin, Ning, Allen Ho, Nareerat Charoenvimolphan, Kai U. Frerichs, Arthur L. Day, and Rose Du. 2013. “Analysis of Morphological Parameters to Differentiate Rupture Status in Anterior Communicating Artery Aneurysms.” PLoS ONE 8 (11): e79635. doi:10.1371/journal.pone.0079635. http://dx.doi.org/10.1371/journal.pone.0079635.
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Abstract: In contrast to size, the association of morphological characteristics of intracranial aneurysms with rupture has not been established in a systematic manner. We present an analysis of the morphological variables that are associated with rupture in anterior communicating artery aneurysms to determine site-specific risk variables. One hundred and twenty-four anterior communicating artery aneurysms were treated in a single institution from 2005 to 2010, and CT angiograms (CTAs) or rotational angiography from 79 patients (42 ruptured, 37 unruptured) were analyzed. Vascular imaging was evaluated with 3D Slicer© to generate models of the aneurysms and surrounding vasculature. Morphological parameters were examined using univariate and multivariate analysis and included aneurysm volume, aspect ratio, size ratio, distance to bifurcation, aneurysm angle, vessel angle, flow angle, and parent-daughter angle. Multivariate logistic regression revealed that size ratio, flow angle, and parent-daughter angle were associated with aneurysm rupture after adjustment for age, sex, smoking history, and other clinical risk factors. Simple morphological parameters such as size ratio, flow angle, and parent-daughter angle may thus aid in the evaluation of rupture risk of anterior communicating artery aneurysms.
Published Version: doi:10.1371/journal.pone.0079635
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827376/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879095
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