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dc.contributor.authorGolwala, Harsh B.en_US
dc.contributor.authorThadani, Udhoen_US
dc.contributor.authorLiang, Lien_US
dc.contributor.authorStavrakis, Stavrosen_US
dc.contributor.authorButler, Javeden_US
dc.contributor.authorYancy, Clyde W.en_US
dc.contributor.authorBhatt, Deepak L.en_US
dc.contributor.authorHernandez, Adrian F.en_US
dc.contributor.authorFonarow, Gregg C.en_US
dc.date.accessioned2014-03-11T02:49:12Z
dc.date.issued2013en_US
dc.identifier.citationGolwala, Harsh B., Udho Thadani, Li Liang, Stavros Stavrakis, Javed Butler, Clyde W. Yancy, Deepak L. Bhatt, Adrian F. Hernandez, and Gregg C. Fonarow. 2013. “Use of Hydralazine‐Isosorbide Dinitrate Combination in African American and Other Race/Ethnic Group Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2 (4): e000214. doi:10.1161/JAHA.113.000214. http://dx.doi.org/10.1161/JAHA.113.000214.en
dc.identifier.issn2047-9980en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879104
dc.description.abstractBackground: Hydralazine‐isosorbide dinitrate (H‐ISDN) therapy is recommended for African American patients with moderate to severe heart failure with reduced ejection fraction (<40%) (HFrEF), but use, temporal trends, and clinical characteristics associated with H‐ISDN therapy in clinical practice are unknown. Methods and Results: An observational analysis of 54 622 patients admitted with HFrEF and discharged home from 207 hospitals participating in the Get With The Guidelines–Heart Failure registry from April 2008 to March 2012 was conducted to assess prescription, trends, and predictors of use of H‐ISDN among eligible patients. Among 11 185 African American patients eligible for H‐ISDN therapy, only 2500 (22.4%) received H‐ISDN therapy at discharge. In the overall eligible population, 5115 of 43 498 (12.6%) received H‐ISDN at discharge. Treatment rates increased over the study period from 16% to 24% among African Americans and from 10% to 13% among the entire HFrEF population. In a multivariable model, factors associated with H‐ISDN use among the entire cohort included younger age; male sex; African American/Hispanic ethnicity; and history of diabetes, hypertension, anemia, renal insufficiency, higher systolic blood pressure, and lower heart rate. In African American patients, these factors were similar; in addition, being uninsured was associated with lower use. Conclusions: Overall, few potentially eligible patients with HFrEF are treated with H‐ISDN, and among African‐Americans fewer than one‐fourth of eligible patients received guideline‐recommended H‐ISDN therapy. Improved ways to facilitate use of H‐ISDN therapy in African American patients with HFrEF are needed.en
dc.language.isoen_USen
dc.publisherBlackwell Publishing Ltden
dc.relation.isversionofdoi:10.1161/JAHA.113.000214en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828812/pdf/en
dash.licenseLAAen_US
dc.subjectHeart Failureen
dc.subjectguideline adherenceen
dc.subjectheart failureen
dc.subjectqualityen
dc.subjectrace/ethnicityen
dc.subjectregistryen
dc.titleUse of Hydralazine‐Isosorbide Dinitrate Combination in African American and Other Race/Ethnic Group Patients With Heart Failure and Reduced Left Ventricular Ejection Fractionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseaseen
dash.depositing.authorBhatt, Deepak L.en_US
dc.date.available2014-03-11T02:49:12Z
dc.identifier.doi10.1161/JAHA.113.000214*
dash.contributor.affiliatedBhatt, Deepak
dc.identifier.orcid0000-0002-1278-6245


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