Animal models of ulcerative colitis and their application in drug research

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Animal models of ulcerative colitis and their application in drug research

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Title: Animal models of ulcerative colitis and their application in drug research
Author: Low, Daren; Nguyen, Deanna D; Mizoguchi, Emiko

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Citation: Low, Daren, Deanna D Nguyen, and Emiko Mizoguchi. 2013. “Animal models of ulcerative colitis and their application in drug research.” Drug Design, Development and Therapy 7 (1): 1341-1357. doi:10.2147/DDDT.S40107. http://dx.doi.org/10.2147/DDDT.S40107.
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Abstract: The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed.
Published Version: doi:10.2147/DDDT.S40107
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829622/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879106
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