Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

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Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

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Title: Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth
Author: Yamashita, Aki; Kawana, Kei; Tomio, Kensuke; Taguchi, Ayumi; Isobe, Yosuke; Iwamoto, Ryo; Masuda, Koji; Furuya, Hitomi; Nagamatsu, Takeshi; Nagasaka, Kazunori; Arimoto, Takahide; Oda, Katsutoshi; Wada-Hiraike, Osamu; Yamashita, Takahiro; Taketani, Yuji; Kang, Jing X.; Kozuma, Shiro; Arai, Hiroyuki; Arita, Makoto; Osuga, Yutaka; Fujii, Tomoyuki

Note: Order does not necessarily reflect citation order of authors.

Citation: Yamashita, A., K. Kawana, K. Tomio, A. Taguchi, Y. Isobe, R. Iwamoto, K. Masuda, et al. 2013. “Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.” Scientific Reports 3 (1): 3113. doi:10.1038/srep03113. http://dx.doi.org/10.1038/srep03113.
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Abstract: Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.
Published Version: doi:10.1038/srep03113
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814804/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879175
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