Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells

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Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells

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Title: Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells
Author: Gazit, Roi; Garrison, Brian S.; Rao, Tata Nageswara; Shay, Tal; Costello, James; Ericson, Jeff; Kim, Francis; Collins, James J.; Regev, Aviv; Wagers, Amy J.; Rossi, Derrick J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Gazit, R., B. Garrison, T. Rao, T. Shay, J. Costello, J. Ericson, F. Kim, et al. 2013. “Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells.” Stem Cell Reports 1 (3): 266-280. doi:10.1016/j.stemcr.2013.07.004. http://dx.doi.org/10.1016/j.stemcr.2013.07.004.
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Abstract: Summary Hematopoietic stem cells (HSCs) maintain blood homeostasis and are the functional units of bone marrow transplantation. To improve the molecular understanding of HSCs and their proximal progenitors, we performed transcriptome analysis within the context of the ImmGen Consortium data set. Gene sets that define steady-state and mobilized HSCs, as well as hematopoietic stem and progenitor cells (HSPCs), were determined. Genes involved in transcriptional regulation, including a group of putative transcriptional repressors, were identified in multipotent progenitors and HSCs. Proximal promoter analyses combined with ImmGen module analysis identified candidate regulators of HSCs. Enforced expression of one predicted regulator, Hlf, in diverse HSPC subsets led to extensive self-renewal activity ex vivo. These analyses reveal unique insights into the mechanisms that control the core properties of HSPCs.
Published Version: doi:10.1016/j.stemcr.2013.07.004
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849420/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879190
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