Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

View/ Open
Author
Hamilton, Mark P.
Rajapakshe, Kimal
Hartig, Sean M.
Reva, Boris
McLellan, Michael D.
Kandoth, Cyriac
Ding, Li
Gunaratne, Preethi H.
Wheeler, David A.
Coarfa, Cristian
McGuire, Sean E.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/ncomms3730Metadata
Show full item recordCitation
Hamilton, M. P., K. Rajapakshe, S. M. Hartig, B. Reva, M. D. McLellan, C. Kandoth, L. Ding, et al. 2013. “Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif.” Nature Communications 4 (1): 2730. doi:10.1038/ncomms3730. http://dx.doi.org/10.1038/ncomms3730.Abstract
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868236/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879197
Collections
- FAS Scholarly Articles [18172]
- HMS Scholarly Articles [17875]
Contact administrator regarding this item (to report mistakes or request changes)