Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

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Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

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Title: Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
Author: Hamilton, Mark P.; Rajapakshe, Kimal; Hartig, Sean M.; Reva, Boris; McLellan, Michael D.; Kandoth, Cyriac; Ding, Li; Zack, Travis I.; Gunaratne, Preethi H.; Wheeler, David A.; Coarfa, Cristian; McGuire, Sean E.

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Citation: Hamilton, M. P., K. Rajapakshe, S. M. Hartig, B. Reva, M. D. McLellan, C. Kandoth, L. Ding, et al. 2013. “Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif.” Nature Communications 4 (1): 2730. doi:10.1038/ncomms3730. http://dx.doi.org/10.1038/ncomms3730.
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Abstract: MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.
Published Version: doi:10.1038/ncomms3730
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868236/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879197
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