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dc.contributor.authorKozuki, Naokoen_US
dc.contributor.authorLee, Anne CCen_US
dc.contributor.authorSilveira, Mariangela Fen_US
dc.contributor.authorSania, Ayeshaen_US
dc.contributor.authorVogel, Joshua Pen_US
dc.contributor.authorAdair, Lindaen_US
dc.contributor.authorBarros, Fernandoen_US
dc.contributor.authorCaulfield, Laura Een_US
dc.contributor.authorChristian, Parulen_US
dc.contributor.authorFawzi, Wafaieen_US
dc.contributor.authorHumphrey, Jeanen_US
dc.contributor.authorHuybregts, Lievenen_US
dc.contributor.authorMongkolchati, Aroonsrien_US
dc.contributor.authorNtozini, Roberten_US
dc.contributor.authorOsrin, Daviden_US
dc.contributor.authorRoberfroid, Dominiqueen_US
dc.contributor.authorTielsch, Jamesen_US
dc.contributor.authorVaidya, Anjanaen_US
dc.contributor.authorBlack, Robert Een_US
dc.contributor.authorKatz, Joanneen_US
dc.date.accessioned2014-03-11T10:15:30Z
dc.date.issued2013en_US
dc.identifier.citationKozuki, N., A. C. Lee, M. F. Silveira, A. Sania, J. P. Vogel, L. Adair, F. Barros, et al. 2013. “The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis.” BMC Public Health 13 (Suppl 3): S2. doi:10.1186/1471-2458-13-S3-S2. http://dx.doi.org/10.1186/1471-2458-13-S3-S2.en
dc.identifier.issn1471-2458en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879212
dc.description.abstractBackground: Previous studies have reported on adverse neonatal outcomes associated with parity and maternal age. Many of these studies have relied on cross-sectional data, from which drawing causal inference is complex. We explore the associations between parity/maternal age and adverse neonatal outcomes using data from cohort studies conducted in low- and middle-income countries (LMIC). Methods: Data from 14 cohort studies were included. Parity (nulliparous, parity 1-2, parity ≥3) and maternal age (<18 years, 18-<35 years, ≥35 years) categories were matched with each other to create exposure categories, with those who are parity 1-2 and age 18-<35 years as the reference. Outcomes included small-for-gestational-age (SGA), preterm, neonatal and infant mortality. Adjusted odds ratios (aOR) were calculated per study and meta-analyzed. Results: Nulliparous, age <18 year women, compared with women who were parity 1-2 and age 18-<35 years had the highest odds of SGA (pooled adjusted OR: 1.80), preterm (pooled aOR: 1.52), neonatal mortality (pooled aOR: 2.07), and infant mortality (pooled aOR: 1.49). Increased odds were also noted for SGA and neonatal mortality for nulliparous/age 18-<35 years, preterm, neonatal, and infant mortality for parity ≥3/age 18-<35 years, and preterm and neonatal mortality for parity ≥3/≥35 years. Conclusions: Nulliparous women <18 years of age have the highest odds of adverse neonatal outcomes. Family planning has traditionally been the least successful in addressing young age as a risk factor; a renewed focus must be placed on finding effective interventions that delay age at first birth. Higher odds of adverse outcomes are also seen among parity ≥3 / age ≥35 mothers, suggesting that reproductive health interventions need to address the entirety of a woman’s reproductive period. Funding Funding was provided by the Bill & Melinda Gates Foundation (810-2054) by a grant to the US Fund for UNICEF to support the activities of the Child Health Epidemiology Reference Group.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1471-2458-13-S3-S2en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847520/pdf/en
dash.licenseLAAen_US
dc.titleThe associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Public Healthen
dash.depositing.authorSania, Ayeshaen_US
dc.date.available2014-03-11T10:15:30Z
dc.identifier.doi10.1186/1471-2458-13-S3-S2*
dash.authorsorderedfalse
dash.contributor.affiliatedSania, Ayesha
dash.contributor.affiliatedFawzi, Wafaie
dc.identifier.orcid0000-0002-2908-600X


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