Show simple item record

dc.contributor.authorCroucher, Nicholas J.en_US
dc.contributor.authorFinkelstein, Jonathan A.en_US
dc.contributor.authorPelton, Stephen I.en_US
dc.contributor.authorMitchell, Patrick K.en_US
dc.contributor.authorLee, Grace M.en_US
dc.contributor.authorParkhill, Julianen_US
dc.contributor.authorBentley, Stephen D.en_US
dc.contributor.authorHanage, William P.en_US
dc.contributor.authorLipsitch, Marcen_US
dc.date.accessioned2014-03-11T10:15:48Z
dc.date.issued2013en_US
dc.identifier.citationCroucher, Nicholas J., Jonathan A. Finkelstein, Stephen I. Pelton, Patrick K. Mitchell, Grace M. Lee, Julian Parkhill, Stephen D. Bentley, William P. Hanage, and Marc Lipsitch. 2013. “Population genomics of post-vaccine changes in pneumococcal epidemiology.” Nature genetics 45 (6): 10.1038/ng.2625. doi:10.1038/ng.2625. http://dx.doi.org/10.1038/ng.2625.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879238
dc.description.abstractWhole genome sequencing of 616 asymptomatically carried pneumococci was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates revealed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant pre-vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the fall in pneumococcal disease rates after the vaccine’s introduction.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.2625en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725542/pdf/en
dash.licenseLAAen_US
dc.titlePopulation genomics of post-vaccine changes in pneumococcal epidemiologyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorCroucher, Nicholas J.en_US
dc.date.available2014-03-11T10:15:48Z
dc.identifier.doi10.1038/ng.2625*
dash.contributor.affiliatedMitchell, Patrick K.
dash.contributor.affiliatedFinkelstein, Jonathan
dash.contributor.affiliatedLee, Grace
dash.contributor.affiliatedHanage, William
dash.contributor.affiliatedCroucher, Nicholas J
dash.contributor.affiliatedLipsitch, Marc


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record