Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

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Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

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dc.contributor.author Samji, Hasina en_US
dc.contributor.author Cescon, Angela en_US
dc.contributor.author Hogg, Robert S. en_US
dc.contributor.author Modur, Sharada P. en_US
dc.contributor.author Althoff, Keri N. en_US
dc.contributor.author Buchacz, Kate en_US
dc.contributor.author Burchell, Ann N. en_US
dc.contributor.author Cohen, Mardge en_US
dc.contributor.author Gebo, Kelly A. en_US
dc.contributor.author Gill, M. John en_US
dc.contributor.author Justice, Amy en_US
dc.contributor.author Kirk, Gregory en_US
dc.contributor.author Klein, Marina B. en_US
dc.contributor.author Korthuis, P. Todd en_US
dc.contributor.author Martin, Jeff en_US
dc.contributor.author Napravnik, Sonia en_US
dc.contributor.author Rourke, Sean B. en_US
dc.contributor.author Sterling, Timothy R. en_US
dc.contributor.author Silverberg, Michael J. en_US
dc.contributor.author Deeks, Stephen en_US
dc.contributor.author Jacobson, Lisa P. en_US
dc.contributor.author Bosch, Ronald J. en_US
dc.contributor.author Kitahata, Mari M. en_US
dc.contributor.author Goedert, James J. en_US
dc.contributor.author Moore, Richard en_US
dc.contributor.author Gange, Stephen J. en_US
dc.date.accessioned 2014-03-11T10:16:07Z
dc.date.issued 2013 en_US
dc.identifier.citation Samji, H., A. Cescon, R. S. Hogg, S. P. Modur, K. N. Althoff, K. Buchacz, A. N. Burchell, et al. 2013. “Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada.” PLoS ONE 8 (12): e81355. doi:10.1371/journal.pone.0081355. http://dx.doi.org/10.1371/journal.pone.0081355. en
dc.identifier.issn 1932-6203 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879268
dc.description.abstract Background: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well characterized. We aim to estimate temporal changes in life expectancy among HIV-positive adults on ART from 2000–2007 in the U.S. and Canada. Methods: Participants were from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), aged ≥20 years and on ART. Mortality rates were calculated using participants' person-time from January 1, 2000 or ART initiation until death, loss to follow-up, or administrative censoring December 31, 2007. Life expectancy at age 20, defined as the average number of additional years that a person of a specific age will live, provided the current age-specific mortality rates remain constant, was estimated using abridged life tables. Results: The crude mortality rate was 19.8/1,000 person-years, among 22,937 individuals contributing 82,022 person-years and 1,622 deaths. Life expectancy increased from 36.1 [standard error (SE) 0.5] to 51.4 [SE 0.5] years from 2000–2002 to 2006–2007. Men and women had comparable life expectancies in all periods except the last (2006–2007). Life expectancy was lower for individuals with a history of injection drug use, non-whites, and in patients with baseline CD4 counts <350 cells/mm3. Conclusions: A 20-year-old HIV-positive adult on ART in the U.S. or Canada is expected to live into their early 70 s, a life expectancy approaching that of the general population. Differences by sex, race, HIV transmission risk group, and CD4 count remain. en
dc.language.iso en_US en
dc.publisher Public Library of Science en
dc.relation.isversionof doi:10.1371/journal.pone.0081355 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867319/pdf/ en
dash.license LAA en_US
dc.subject Medicine en
dc.subject Epidemiology en
dc.subject Epidemiological Methods en
dc.subject Infectious Disease Epidemiology en
dc.subject Infectious Diseases en
dc.subject Sexually Transmitted Diseases en
dc.subject AIDS en
dc.subject Viral Diseases en
dc.subject HIV en
dc.subject HIV diagnosis and management en
dc.subject HIV epidemiology en
dc.subject Non-Clinical Medicine en
dc.subject Health Care Policy en
dc.subject Health Statistics en
dc.subject Public Health en
dc.title Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal PLoS ONE en
dash.depositing.author Bosch, Ronald J. en_US
dc.date.available 2014-03-11T10:16:07Z

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