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dc.contributor.authorSamji, Hasinaen_US
dc.contributor.authorCescon, Angelaen_US
dc.contributor.authorHogg, Robert S.en_US
dc.contributor.authorModur, Sharada P.en_US
dc.contributor.authorAlthoff, Keri N.en_US
dc.contributor.authorBuchacz, Kateen_US
dc.contributor.authorBurchell, Ann N.en_US
dc.contributor.authorCohen, Mardgeen_US
dc.contributor.authorGebo, Kelly A.en_US
dc.contributor.authorGill, M. Johnen_US
dc.contributor.authorJustice, Amyen_US
dc.contributor.authorKirk, Gregoryen_US
dc.contributor.authorKlein, Marina B.en_US
dc.contributor.authorKorthuis, P. Todden_US
dc.contributor.authorMartin, Jeffen_US
dc.contributor.authorNapravnik, Soniaen_US
dc.contributor.authorRourke, Sean B.en_US
dc.contributor.authorSterling, Timothy R.en_US
dc.contributor.authorSilverberg, Michael J.en_US
dc.contributor.authorDeeks, Stephenen_US
dc.contributor.authorJacobson, Lisa P.en_US
dc.contributor.authorBosch, Ronald J.en_US
dc.contributor.authorKitahata, Mari M.en_US
dc.contributor.authorGoedert, James J.en_US
dc.contributor.authorMoore, Richarden_US
dc.contributor.authorGange, Stephen J.en_US
dc.date.accessioned2014-03-11T10:16:07Z
dc.date.issued2013en_US
dc.identifier.citationSamji, H., A. Cescon, R. S. Hogg, S. P. Modur, K. N. Althoff, K. Buchacz, A. N. Burchell, et al. 2013. “Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada.” PLoS ONE 8 (12): e81355. doi:10.1371/journal.pone.0081355. http://dx.doi.org/10.1371/journal.pone.0081355.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879268
dc.description.abstractBackground: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well characterized. We aim to estimate temporal changes in life expectancy among HIV-positive adults on ART from 2000–2007 in the U.S. and Canada. Methods: Participants were from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), aged ≥20 years and on ART. Mortality rates were calculated using participants' person-time from January 1, 2000 or ART initiation until death, loss to follow-up, or administrative censoring December 31, 2007. Life expectancy at age 20, defined as the average number of additional years that a person of a specific age will live, provided the current age-specific mortality rates remain constant, was estimated using abridged life tables. Results: The crude mortality rate was 19.8/1,000 person-years, among 22,937 individuals contributing 82,022 person-years and 1,622 deaths. Life expectancy increased from 36.1 [standard error (SE) 0.5] to 51.4 [SE 0.5] years from 2000–2002 to 2006–2007. Men and women had comparable life expectancies in all periods except the last (2006–2007). Life expectancy was lower for individuals with a history of injection drug use, non-whites, and in patients with baseline CD4 counts <350 cells/mm3. Conclusions: A 20-year-old HIV-positive adult on ART in the U.S. or Canada is expected to live into their early 70 s, a life expectancy approaching that of the general population. Differences by sex, race, HIV transmission risk group, and CD4 count remain.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0081355en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867319/pdf/en
dash.licenseLAAen_US
dc.subjectMedicineen
dc.subjectEpidemiologyen
dc.subjectEpidemiological Methodsen
dc.subjectInfectious Disease Epidemiologyen
dc.subjectInfectious Diseasesen
dc.subjectSexually Transmitted Diseasesen
dc.subjectAIDSen
dc.subjectViral Diseasesen
dc.subjectHIVen
dc.subjectHIV diagnosis and managementen
dc.subjectHIV epidemiologyen
dc.subjectNon-Clinical Medicineen
dc.subjectHealth Care Policyen
dc.subjectHealth Statisticsen
dc.subjectPublic Healthen
dc.titleClosing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canadaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorBosch, Ronald J.en_US
dc.date.available2014-03-11T10:16:07Z
dc.identifier.doi10.1371/journal.pone.0081355*
dash.authorsorderedfalse
dash.contributor.affiliatedBosch, Ronald


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