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dc.contributor.authorHu, Jieen_US
dc.contributor.authorLocasale, Jason W.en_US
dc.contributor.authorBielas, Jason H.en_US
dc.contributor.authorO’Sullivan, Jacinthaen_US
dc.contributor.authorSheahan, Kieranen_US
dc.contributor.authorCantley, Lewis C.en_US
dc.contributor.authorVander Heiden, Matthew G.en_US
dc.contributor.authorVitkup, Dennisen_US
dc.date.accessioned2014-03-11T10:16:50Z
dc.date.issued2013en_US
dc.identifier.citationHu, Jie, Jason W. Locasale, Jason H. Bielas, Jacintha O’Sullivan, Kieran Sheahan, Lewis C. Cantley, Matthew G. Vander Heiden, and Dennis Vitkup. 2013. “Heterogeneity of tumor-induced gene expression changes in the human metabolic network.” Nature biotechnology 31 (6): 522-529. doi:10.1038/nbt.2530. http://dx.doi.org/10.1038/nbt.2530.en
dc.identifier.issn1087-0156en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879311
dc.description.abstractReprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how metabolic gene expression in tumors differs from that in normal tissues, or whether different tumor types exhibit similar metabolic changes. Here we compare expression patterns of metabolic genes across 22 diverse types of human tumors. Overall, the metabolic gene expression program in tumors is similar to that in the corresponding normal tissues. Although expression changes of some metabolic pathways (e.g., up-regulation of nucleotide biosynthesis and glycolysis) are frequently observed across tumors, expression changes of other pathways (e.g., oxidative phosphorylation and the tricarboxylic acid (TCA) cycle) are very heterogeneous. Our analysis also suggests that the expression changes of major metabolic processes across tumors can be rationalized in terms of several principal components. On the level of individual biochemical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expression changes. These isoenzymes are potential targets for anticancer therapy.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nbt.2530en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681899/pdf/en
dash.licenseLAAen_US
dc.titleHeterogeneity of tumor-induced gene expression changes in the human metabolic networken
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature biotechnologyen
dc.date.available2014-03-11T10:16:50Z
dc.identifier.doi10.1038/nbt.2530*


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