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dc.contributor.authorKim, Myung-Sunnyen_US
dc.contributor.authorYamamoto, Yasuhikoen_US
dc.contributor.authorKim, Kyungjinen_US
dc.contributor.authorKamei, Nozomuen_US
dc.contributor.authorShimada, Takeshien_US
dc.contributor.authorLiu, Libinen_US
dc.contributor.authorMoore, Kristinen_US
dc.contributor.authorWoo, Ju Rangen_US
dc.contributor.authorShoelson, Steven E.en_US
dc.contributor.authorLee, Jongsoonen_US
dc.date.accessioned2014-03-11T10:17:34Z
dc.date.issued2013en_US
dc.identifier.citationKim, Myung-Sunny, Yasuhiko Yamamoto, Kyungjin Kim, Nozomu Kamei, Takeshi Shimada, Libin Liu, Kristin Moore, Ju Rang Woo, Steven E. Shoelson, and Jongsoon Lee. 2013. “Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone.” PLoS ONE 8 (12): e82847. doi:10.1371/journal.pone.0082847. http://dx.doi.org/10.1371/journal.pone.0082847.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879393
dc.description.abstractIt is increasingly accepted that chronic inflammation participates in obesity-induced insulin resistance and type 2 diabetes (T2D). Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic properties. The present study compared the effects of these drugs on obesity-induced inflammation in adipose tissue (AT) and AT macrophages (ATMs), as well as the metabolic and immunological phenotypes of the animal models. Both drugs improved high fat diet (HFD)-induced insulin resistance. However, salicylates did not affect AT and ATM inflammation, whereas Pioglitazone improved these parameters. Interestingly, HFD and the drug treatments all modulated systemic inflammation as assessed by changes in circulating immune cell numbers and activation states. HFD increased the numbers of circulating white blood cells, neutrophils, and a pro-inflammatory monocyte subpopulation (Ly6Chi), whereas salicylates and Pioglitazone normalized these cell numbers. The drug treatments also decreased circulating lymphocyte numbers. These data suggest that obesity induces systemic inflammation by regulating circulating immune cell phenotypes and that anti-diabetic interventions suppress systemic inflammation by normalizing circulating immune phenotypes.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0082847en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871540/pdf/en
dash.licenseLAAen_US
dc.titleRegulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazoneen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorShoelson, Steven E.en_US
dc.date.available2014-03-11T10:17:34Z
dc.identifier.doi10.1371/journal.pone.0082847*
dash.authorsorderedfalse
dash.contributor.affiliatedLee, Jongsoon
dash.contributor.affiliatedShoelson, Steven


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