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dc.contributor.authorMerritt, Melissa A.en_US
dc.contributor.authorBentink, Stefanen_US
dc.contributor.authorSchwede, Matthewen_US
dc.contributor.authorIwanicki, Marcin P.en_US
dc.contributor.authorQuackenbush, Johnen_US
dc.contributor.authorWoo, Terrien_US
dc.contributor.authorAgoston, Elin S.en_US
dc.contributor.authorReinhardt, Ferencen_US
dc.contributor.authorCrum, Christopher P.en_US
dc.contributor.authorBerkowitz, Ross S.en_US
dc.contributor.authorMok, Samuel C.en_US
dc.contributor.authorWitt, Abigail E.en_US
dc.contributor.authorJones, Michelle A.en_US
dc.contributor.authorWang, Binen_US
dc.contributor.authorInce, Tan A.en_US
dc.date.accessioned2014-03-11T10:17:50Z
dc.date.issued2013en_US
dc.identifier.citationMerritt, M. A., S. Bentink, M. Schwede, M. P. Iwanicki, J. Quackenbush, T. Woo, E. S. Agoston, et al. 2013. “Gene Expression Signature of Normal Cell-of-Origin Predicts Ovarian Tumor Outcomes.” PLoS ONE 8 (11): e80314. doi:10.1371/journal.pone.0080314. http://dx.doi.org/10.1371/journal.pone.0080314.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879429
dc.description.abstractThe potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype and outcome. Here we describe a new cell culture medium for in vitro culture of paired normal human ovarian (OV) and fallopian tube (FT) epithelial cells from donors without cancer. While these cells have been cultured individually for short periods of time, to our knowledge this is the first long-term culture of both cell types from the same donors. Through analysis of the gene expression profiles of the cultured OV/FT cells we identified a normal cell-of-origin gene signature that classified primary ovarian cancers into OV-like and FT-like subgroups; this classification correlated with significant differences in clinical outcomes. The identification of a prognostically significant gene expression signature derived solely from normal untransformed cells is consistent with the hypothesis that the normal cell-of-origin may be a source of ovarian tumor heterogeneity and the associated differences in tumor outcome.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0080314en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841174/pdf/en
dash.licenseLAAen_US
dc.titleGene Expression Signature of Normal Cell-of-Origin Predicts Ovarian Tumor Outcomesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorIwanicki, Marcin P.en_US
dc.date.available2014-03-11T10:17:50Z
dc.identifier.doi10.1371/journal.pone.0080314*
dash.authorsorderedfalse
dash.contributor.affiliatedIwanicki, Marcin
dash.contributor.affiliatedCrum, Christopher
dash.contributor.affiliatedBerkowitz, Ross


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