dc.contributor.author | Mingueneau, Michael | en_US |
dc.contributor.author | Kreslavsky, Taras | en_US |
dc.contributor.author | Gray, Daniel | en_US |
dc.contributor.author | Heng, Tracy | en_US |
dc.contributor.author | Cruse, Richard | en_US |
dc.contributor.author | Ericson, Jeffrey | en_US |
dc.contributor.author | Bendall, Sean | en_US |
dc.contributor.author | Spitzer, Matt | en_US |
dc.contributor.author | Nolan, Garry | en_US |
dc.contributor.author | Kobayashi, Koichi | en_US |
dc.contributor.author | von Boehmer, Harald | en_US |
dc.contributor.author | Mathis, Diane | en_US |
dc.contributor.author | Benoist, Christophe | en_US |
dc.date.accessioned | 2014-03-11T10:17:52Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Mingueneau, M., T. Kreslavsky, D. Gray, T. Heng, R. Cruse, J. Ericson, S. Bendall, et al. 2013. “The transcriptional landscape of αβ T cell differentiation.” Nature immunology 14 (6): 10.1038/ni.2590. doi:10.1038/ni.2590. http://dx.doi.org/10.1038/ni.2590. | en |
dc.identifier.issn | 1529-2908 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879434 | |
dc.description.abstract | αβT cell differentiation from thymic precursors is a complex process, explored here with the breadth of ImmGen expression datasets, analyzing how differentiation of thymic precursors gives rise to transcriptomes. After surprisingly gradual changes though early T commitment, transit through the CD4+CD8+ stage involves a shutdown or rare breadth, and correlating tightly with MYC. MHC-driven selection promotes a large-scale transcriptional reactivation. We identify distinct signatures that mark cells destined for positive selection versus apoptotic deletion. Differential expression of surprisingly few genes accompany CD4 or CD8 commitment, a similarity that carries through to peripheral T cells and their activation, revealed by mass cytometry phosphoproteomics. The novel transcripts identified as candidate mediators of key transitions help define the “known unknown” of thymocyte differentiation. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ni.2590 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660436/pdf/ | en |
dash.license | LAA | en_US |
dc.title | The transcriptional landscape of αβ T cell differentiation | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature immunology | en |
dash.depositing.author | Cruse, Richard | en_US |
dc.date.available | 2014-03-11T10:17:52Z | |
dc.identifier.doi | 10.1038/ni.2590 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Cruse, Richard | |
dash.contributor.affiliated | Mathis, Diane | |
dash.contributor.affiliated | Benoist, Christophe | |