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dc.contributor.authorKim, Danielen_US
dc.contributor.authorZai, Lailaen_US
dc.contributor.authorLiang, Pengen_US
dc.contributor.authorSchaffling, Colleenen_US
dc.contributor.authorAhlborn, Daviden_US
dc.contributor.authorBenowitz, Larry I.en_US
dc.date.accessioned2014-03-11T10:17:55Z
dc.date.issued2013en_US
dc.identifier.citationKim, Daniel, Laila Zai, Peng Liang, Colleen Schaffling, David Ahlborn, and Larry I. Benowitz. 2013. “Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury.” PLoS ONE 8 (12): e81948. doi:10.1371/journal.pone.0081948. http://dx.doi.org/10.1371/journal.pone.0081948.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879441
dc.description.abstractAlthough corticospinal tract axons cannot regenerate long distances after spinal cord injury, they are able to sprout collateral branches rostral to an injury site that can help form compensatory circuits in cases of incomplete lesions. We show here that inosine enhances the formation of compensatory circuits after a dorsal hemisection of the thoracic spinal cord in mature rats and improves coordinated limb use. Inosine is a naturally occurring metabolite of adenosine that crosses the cell membrane and, in neurons, activates Mst3b, a protein kinase that is part of a signal transduction pathway that regulates axon outgrowth. Compared to saline-treated controls, rats with dorsal hemisections that were treated with inosine showed three times as many synaptic contacts between corticospinal tract collaterals and long propriospinal interneurons that project from the cervical cord to the lumbar level. Inosine-treated rats also showed stronger serotonergic reinnervation of the lumbar cord than saline-treated controls, and performed well above controls in both open-field testing and a horizontal ladder rung-walking test. Inosine was equally effective whether delivered intracranially or intravenously, and has been shown to be safe for other indications in humans. Thus, inosine might be a useful therapeutic for improving outcome after spinal cord injury.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0081948en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846725/pdf/en
dash.licenseLAAen_US
dc.titleInosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injuryen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorLiang, Pengen_US
dc.date.available2014-03-11T10:17:55Z
dc.identifier.doi10.1371/journal.pone.0081948*
dash.contributor.affiliatedLiang, Peng
dash.contributor.affiliatedBenowitz, Larry


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