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dc.contributor.authorDjoussé, Lucen_US
dc.contributor.authorMaziarz, Marlenaen_US
dc.contributor.authorBiggs, Mary L.en_US
dc.contributor.authorIx, Joachim H.en_US
dc.contributor.authorZieman, Susan J.en_US
dc.contributor.authorKizer, Jorge R.en_US
dc.contributor.authorLemaitre, Rozenn N.en_US
dc.contributor.authorMozaffarian, Dariushen_US
dc.contributor.authorTracy, Russell P.en_US
dc.contributor.authorMukamal, Kenneth J.en_US
dc.contributor.authorSiscovick, David S.en_US
dc.contributor.authorSotoodehnia, Nonaen_US
dc.date.accessioned2014-03-11T13:25:22Z
dc.date.issued2013en_US
dc.identifier.citationDjoussé, L., M. Maziarz, M. L. Biggs, J. H. Ix, S. J. Zieman, J. R. Kizer, R. N. Lemaitre, et al. 2013. “Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults.” Cardiology Research and Practice 2013 (1): 181054. doi:10.1155/2013/181054. http://dx.doi.org/10.1155/2013/181054.en
dc.identifier.issn2090-8016en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879490
dc.description.abstractAlthough fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95–1.38), P = 0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07–1.65), P = 0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62–1.27), P = 0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2013/181054en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888692/pdf/en
dash.licenseLAAen_US
dc.titlePlasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adultsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCardiology Research and Practiceen
dash.depositing.authorDjoussé, Lucen_US
dc.date.available2014-03-11T13:25:22Z
dc.identifier.doi10.1155/2013/181054*
dash.authorsorderedfalse
dash.contributor.affiliatedDjousse, Luc
dash.contributor.affiliatedMozaffarian, Dariush
dash.contributor.affiliatedMukamal, Kenneth


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