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dc.contributor.authorZhou, Lien_US
dc.contributor.authorHe, Meianen_US
dc.contributor.authorMo, Zengnanen_US
dc.contributor.authorWu, Chenen_US
dc.contributor.authorYang, Handongen_US
dc.contributor.authorYu, Diankeen_US
dc.contributor.authorYang, Xiaoboen_US
dc.contributor.authorZhang, Xiaominen_US
dc.contributor.authorWang, Yiqinen_US
dc.contributor.authorSun, Jielinen_US
dc.contributor.authorGao, Yongen_US
dc.contributor.authorTan, Aihuaen_US
dc.contributor.authorHe, Yunfengen_US
dc.contributor.authorZhang, Haiyingen_US
dc.contributor.authorQin, Xueen_US
dc.contributor.authorZhu, Jingwenen_US
dc.contributor.authorLi, Huaixingen_US
dc.contributor.authorLin, Xuen_US
dc.contributor.authorZhu, Jiangen_US
dc.contributor.authorMin, Xinwenen_US
dc.contributor.authorLang, Mingjianen_US
dc.contributor.authorLi, Dongfengen_US
dc.contributor.authorZhai, Kanen_US
dc.contributor.authorChang, Jiangen_US
dc.contributor.authorTan, Wenen_US
dc.contributor.authorYuan, Jingen_US
dc.contributor.authorChen, Weihongen_US
dc.contributor.authorWang, Youjieen_US
dc.contributor.authorWei, Shengen_US
dc.contributor.authorMiao, Xiaopingen_US
dc.contributor.authorWang, Fengen_US
dc.contributor.authorFang, Weiminen_US
dc.contributor.authorLiang, Yuanen_US
dc.contributor.authorDeng, Qifeien_US
dc.contributor.authorDai, Xiayunen_US
dc.contributor.authorLin, Dafengen_US
dc.contributor.authorHuang, Sulien_US
dc.contributor.authorGuo, Huanen_US
dc.contributor.authorLilly Zheng, S.en_US
dc.contributor.authorXu, Jianfengen_US
dc.contributor.authorLin, Dongxinen_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorWu, Tangchunen_US
dc.date.accessioned2014-03-11T13:25:31Z
dc.date.issued2013en_US
dc.identifier.citationZhou, L., M. He, Z. Mo, C. Wu, H. Yang, D. Yu, X. Yang, et al. 2013. “A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population.” PLoS ONE 8 (12): e82420. doi:10.1371/journal.pone.0082420. http://dx.doi.org/10.1371/journal.pone.0082420.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879514
dc.description.abstractPlasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In order to identify genetic markers for lipid levels in a Chinese population and analyze the heterogeneity between Europeans and Asians, especially Chinese, we performed a meta-analysis of two genome wide association studies on four common lipid traits including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) in a Han Chinese population totaling 3,451 healthy subjects. Replication was performed in an additional 8,830 subjects of Han Chinese ethnicity. We replicated eight loci associated with lipid levels previously reported in a European population. The loci genome wide significantly associated with TC were near DOCK7, HMGCR and ABO; those genome wide significantly associated with TG were near APOA1/C3/A4/A5 and LPL; those genome wide significantly associated with LDL were near HMGCR, ABO and TOMM40; and those genome wide significantly associated with HDL were near LPL, LIPC and CETP. In addition, an additive genotype score of eight SNPs representing the eight loci that were found to be associated with lipid levels was associated with higher TC, TG and LDL levels (P = 5.52×10-16, 1.38×10-6 and 5.59×10-9, respectively). These findings suggest the cumulative effects of multiple genetic loci on plasma lipid levels. Comparisons with previous GWAS of lipids highlight heterogeneity in allele frequency and in effect size for some loci between Chinese and European populations. The results from our GWAS provided comprehensive and convincing evidence of the genetic determinants of plasma lipid levels in a Chinese population.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0082420en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875415/pdf/en
dash.licenseLAAen_US
dc.titleA Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Populationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHu, Frank B.en_US
dc.date.available2014-03-11T13:25:31Z
dc.identifier.doi10.1371/journal.pone.0082420*
dash.authorsorderedfalse
dash.contributor.affiliatedHu, Frank


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