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dc.contributor.authorFang, Shenyingen_US
dc.contributor.authorHan, Jialien_US
dc.contributor.authorZhang, Mingfengen_US
dc.contributor.authorWang, Li-een_US
dc.contributor.authorWei, Qingyien_US
dc.contributor.authorAmos, Christopher I.en_US
dc.contributor.authorLee, Jeffrey E.en_US
dc.date.accessioned2014-03-11T13:25:33Z
dc.date.issued2013en_US
dc.identifier.citationFang, Shenying, Jiali Han, Mingfeng Zhang, Li-e Wang, Qingyi Wei, Christopher I. Amos, and Jeffrey E. Lee. 2013. “Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility.” PLoS ONE 8 (12): e85642. doi:10.1371/journal.pone.0085642. http://dx.doi.org/10.1371/journal.pone.0085642.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879517
dc.description.abstractSingle genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and Harvard Medical School investigations. Participants with ≥15 risk alleles were 5-fold more likely to have melanoma compared to those carrying ≤6. Compared to a model using the most significant single variant rs12913832, the increase in predictive value for the model using a polygenic risk score (PRS) comprised of 11 SNPs was 0.07(95% CI, 0.05-0.07). The overall predictive value of the PRS together with conventional phenotypic factors in the MDACC population was 0.69 (95% CI, 0.64-0.69). PRS significantly improved the risk prediction and reclassification in melanoma as compared with the conventional model. Our study suggests that a polygenic profile can improve the predictive value of an individual gene polymorphism and may be able to significantly improve the predictive value beyond conventional phenotypic melanoma risk factors.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0085642en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877376/pdf/en
dash.licenseLAAen_US
dc.titleJoint Effect of Multiple Common SNPs Predicts Melanoma Susceptibilityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHan, Jialien_US
dc.date.available2014-03-11T13:25:33Z
dc.identifier.doi10.1371/journal.pone.0085642*
dash.contributor.affiliatedZhang, Mingfeng
dash.contributor.affiliatedHan, Jiali


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