Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach

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Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach

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Title: Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach
Author: Huang, Tao; Ren, JingJing; Huang, Jinyan; Li, Duo

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Citation: Huang, Tao, JingJing Ren, Jinyan Huang, and Duo Li. 2013. “Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach.” BMC Genomics 14 (1): 867. doi:10.1186/1471-2164-14-867. http://dx.doi.org/10.1186/1471-2164-14-867.
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Abstract: Background: We tested the hypothesis that elevated homocysteine (Hcy) level is causally associated with increased risk of type 2 diabetes mellitus (T2DM). Results: The meta-analysis and Mendelian randomization analysis were performed among 4011 cases and 4303 controls. The absolute pooled mean Hcy concentration in subjects with MTHFR 677TT was 5.55 μmol/L (95% CI, 1.33 to 9.77) greater than that in subjects with MTHFR 677CC in T2DM. Overall, the T allele of the MTHFR 677 C > T conferred a greater risk for T2DM [Random effect (RE) OR = 1.31(1.17-1.64), I2 = 41.0%, p = 0.055]. The random effect (RE) pooled OR associated with T2DM for MTHFR 677TT relative to the 677CC was [RE OR = 1.38(1.18-1.62)]. The fixed-effect pooled OR of the association for the MTHFR 677 TT vs CT was 1.29 (95% CI, 1.09-1.51). MTHFR 677 TT showed a significantly higher risk for T2DM compared with MTHFR 677 CC + CT [Fixed effect (FE) OR = 1.32(1.14-1.54), I2 = 0.0%, p = 0.686]. The absolute pooled mean Hcy concentration in individuals with T2DM was 0.94 μmol/L (95% CI, 0.40-1.48) greater than that in control subjects. The estimated causal OR associated with T2DM was 1.29 for 5 μmol/L increment in Hcy. Conclusions: Our findings provided strong evidence on the causal association of Hcy level with the development of T2DM.
Published Version: doi:10.1186/1471-2164-14-867
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878883/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879539
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