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dc.contributor.authorBlack, Kendra M.en_US
dc.contributor.authorMasuzawa, Akihiroen_US
dc.contributor.authorHagberg, Robert C.en_US
dc.contributor.authorKhabbaz, Kamal R.en_US
dc.contributor.authorTrovato, Mary E.en_US
dc.contributor.authorRettagliati, Verna M.en_US
dc.contributor.authorBhasin, Manoj K.en_US
dc.contributor.authorDillon, Simon T.en_US
dc.contributor.authorLibermann, Towia A.en_US
dc.contributor.authorToumpoulis, Ioannis K.en_US
dc.contributor.authorLevitsky, Sidneyen_US
dc.contributor.authorMcCully, James D.en_US
dc.date.accessioned2014-03-11T13:26:37Z
dc.date.issued2013en_US
dc.identifier.citationBlack, K. M., A. Masuzawa, R. C. Hagberg, K. R. Khabbaz, M. E. Trovato, V. M. Rettagliati, M. K. Bhasin, et al. 2013. “Preliminary Biomarkers for Identification of Human Ascending Thoracic Aortic Aneurysm.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2 (6): e000138. doi:10.1161/JAHA.113.000138. http://dx.doi.org/10.1161/JAHA.113.000138.en
dc.identifier.issn2047-9980en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879586
dc.description.abstractBackground: Human ascending thoracic aortic aneurysms (ATAAs) are life threatening and constitute a leading cause of mortality in the United States. Previously, we demonstrated that collagens α2(V) and α1(XI) mRNA and protein expression levels are significantly increased in ATAAs. Methods and Results: In this report, the authors extended these preliminary studies using high‐throughput proteomic analysis to identify additional biomarkers for use in whole blood real‐time RT‐PCR analysis to allow for the identification of ATAAs before dissection or rupture. Human ATAA samples were obtained from male and female patients aged 65±14 years. Both bicuspid and tricuspid aortic valve patients were included and compared with nonaneurysmal aortas (mean diameter 2.3 cm). Five biomarkers were identified as being suitable for detection and identification of ATAAs using qRT‐PCR analysis of whole blood. Analysis of 41 samples (19 small, 13 medium‐sized, and 9 large ATAAs) demonstrated the overexpression of 3 of these transcript biomarkers correctly identified 79.4% of patients with ATAA of ≥4.0 cm (P<0.001, sensitivity 0.79, CI=0.62 to 0.91; specificity 1.00, 95% CI=0.42 to 1.00). Conclusion: A preliminary transcript biomarker panel for the identification of ATAAs using whole blood qRT‐PCR analysis in men and women is presented.en
dc.language.isoen_USen
dc.publisherBlackwell Publishing Ltden
dc.relation.isversionofdoi:10.1161/JAHA.113.000138en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886733/pdf/en
dash.licenseLAAen_US
dc.subjectVascular Medicineen
dc.subjectascending thoracic aortic aneurysmen
dc.subjectcollagenen
dc.subjectFHL1en
dc.titlePreliminary Biomarkers for Identification of Human Ascending Thoracic Aortic Aneurysmen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseaseen
dash.depositing.authorKhabbaz, Kamal R.en_US
dc.date.available2014-03-11T13:26:37Z
dc.identifier.doi10.1161/JAHA.113.000138*
dash.authorsorderedfalse
dash.contributor.affiliatedMcCully, James
dash.contributor.affiliatedDillon, Simon
dash.contributor.affiliatedLevitsky, Sidney
dash.contributor.affiliatedBhasin, Manoj
dash.contributor.affiliatedLibermann, Towia
dash.contributor.affiliatedKhabbaz, Kamal


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