CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

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CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

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Title: CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Author: Bradshaw, Elizabeth M; Chibnik, Lori B; Keenan, Brendan T; Ottoboni, Linda; Raj, Towfique; Tang, Anna; Rosenkrantz, Laura L; Imboywa, Selina; Lee, Michelle; Von Korff, Alina; Morris, Martha C; Evans, Denis A; Johnson, Keith; Sperling, Reisa A; Schneider, Julie A; Bennett, David A; De Jager, Philip L

Note: Order does not necessarily reflect citation order of authors.

Citation: Bradshaw, E. M., L. B. Chibnik, B. T. Keenan, L. Ottoboni, T. Raj, A. Tang, L. L. Rosenkrantz, et al. 2013. “CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology.” Nature neuroscience 16 (7): 10.1038/nn.3435. doi:10.1038/nn.3435. http://dx.doi.org/10.1038/nn.3435.
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Abstract: In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia.
Published Version: doi:10.1038/nn.3435
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879590
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