CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

 
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Keenan, Brendan T
Tang, Anna
Rosenkrantz, Laura L
Imboywa, Selina
Von Korff, Alina
Morris, Martha C
Evans, Denis A
Schneider, Julie A
Bennett, David A
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nn.3435
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Citation
Bradshaw, E. M., L. B. Chibnik, B. T. Keenan, L. Ottoboni, T. Raj, A. Tang, L. L. Rosenkrantz, et al. 2013. “CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology.” Nature neuroscience 16 (7): 10.1038/nn.3435. doi:10.1038/nn.3435. http://dx.doi.org/10.1038/nn.3435.
Abstract
In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879590

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