Inhibition of Cdc42 during mitotic exit is required for cytokinesis

DSpace/Manakin Repository

Inhibition of Cdc42 during mitotic exit is required for cytokinesis

Citable link to this page

 

 
Title: Inhibition of Cdc42 during mitotic exit is required for cytokinesis
Author: Atkins, Benjamin D.; Yoshida, Satoshi; Saito, Koji; Wu, Chi-Fang; Lew, Daniel J.; Pellman, David

Note: Order does not necessarily reflect citation order of authors.

Citation: Atkins, Benjamin D., Satoshi Yoshida, Koji Saito, Chi-Fang Wu, Daniel J. Lew, and David Pellman. 2013. “Inhibition of Cdc42 during mitotic exit is required for cytokinesis.” The Journal of Cell Biology 202 (2): 231-240. doi:10.1083/jcb.201301090. http://dx.doi.org/10.1083/jcb.201301090.
Full Text & Related Files:
Abstract: The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an important upstream cell cycle regulator that suppresses Cdc42 activity. Failure to down-regulate Cdc42 during mitotic exit impairs the normal localization of key cytokinesis regulators—Iqg1 and Inn1—at the division site, and results in an abnormal septum. The effects of Cdc42 hyperactivation are largely mediated by the Cdc42 effector p21-activated kinase Ste20. Inhibition of Cdc42 and related Rho guanosine triphosphatases may be a general feature of cytokinesis in eukaryotes.
Published Version: doi:10.1083/jcb.201301090
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718968/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879618
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters