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dc.contributor.authorYu, Nanzeen_US
dc.contributor.authorLong, Xiaoen_US
dc.contributor.authorLujan-Hernandez, Jorge Ren_US
dc.contributor.authorHassan, Kazi Zen_US
dc.contributor.authorBai, Mingen_US
dc.contributor.authorWang, Yangen_US
dc.contributor.authorWang, Xiaojunen_US
dc.contributor.authorZhao, Ruen_US
dc.date.accessioned2014-03-11T13:27:05Z
dc.date.issued2013en_US
dc.identifier.citationYu, Nanze, Xiao Long, Jorge R Lujan-Hernandez, Kazi Z Hassan, Ming Bai, Yang Wang, Xiaojun Wang, and Ru Zhao. 2013. “Marjolin’s ulcer: a preventable malignancy arising from scars.” World Journal of Surgical Oncology 11 (1): 313. doi:10.1186/1477-7819-11-313. http://dx.doi.org/10.1186/1477-7819-11-313.en
dc.identifier.issn1477-7819en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879626
dc.description.abstractBackground: Marjolin’s ulcer (MU) is a rare malignancy arising from various forms of scars. This potentially fatal complication typically occurs after a certain latency period. This article attempts to reveal the importance of the latency period in the prevention and early treatment of the malignancy. Methods: A retrospective review of 17 MU patients who underwent surgical procedures between June of 2005 and December 2011 was conducted. Etiology of injuries, latency period, repeated ulceration, and outcomes were recorded. This observational report reveals characteristics of patients who develop MU. Results: An incidence of 0.7% of MU was found amongst patients complaining of existing scars in our study; burns and trauma were the most common etiology of MU. The mean latency period was 29 years (SD = 19) and the mean post-ulceration period was 7 years (SD = 9). Statistical analysis revealed a negative correlation between the age of patients at injury and the length of latency period (r = −0.8, P <0.01), as well as the lengths of pre-ulceration and post-ulceration periods (r = −0.7, P <0.01). Conclusions: Patients experience different lengths of pre- and post-ulceration periods during the latency period. Younger patients tend to have a longer latency period. Skin breakdown on chronic scars and chronic unhealed ulcers are two main sources of MU. MU may be preventable with a close surveillance of the ulcer during the latency period.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1477-7819-11-313en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896958/pdf/en
dash.licenseLAAen_US
dc.subjectMarjolin’s ulceren
dc.subjectSquamous cell carcinomaen
dc.titleMarjolin’s ulcer: a preventable malignancy arising from scarsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalWorld Journal of Surgical Oncologyen
dc.date.available2014-03-11T13:27:05Z
dc.identifier.doi10.1186/1477-7819-11-313*
dash.authorsorderedfalse


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