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dc.contributor.authorMartin-Montalvo, Alejandroen_US
dc.contributor.authorMercken, Evi M.en_US
dc.contributor.authorMitchell, Sarah J.en_US
dc.contributor.authorPalacios, Hector H.en_US
dc.contributor.authorMote, Patricia L.en_US
dc.contributor.authorScheibye-Knudsen, Mortenen_US
dc.contributor.authorGomes, Ana P.en_US
dc.contributor.authorWard, Theresa M.en_US
dc.contributor.authorMinor, Robin K.en_US
dc.contributor.authorBlouin, Marie-Joséen_US
dc.contributor.authorSchwab, Matthiasen_US
dc.contributor.authorPollak, Michaelen_US
dc.contributor.authorZhang, Yongqingen_US
dc.contributor.authorYu, Yinbingen_US
dc.contributor.authorBecker, Kevin G.en_US
dc.contributor.authorBohr, Vilhelm A.en_US
dc.contributor.authorIngram, Donald K.en_US
dc.contributor.authorSinclair, David A.en_US
dc.contributor.authorWolf, Norman S.en_US
dc.contributor.authorSpindler, Stephen R.en_US
dc.contributor.authorBernier, Michelen_US
dc.contributor.authorde Cabo, Rafaelen_US
dc.date.accessioned2014-03-11T13:27:16Z
dc.date.issued2013en_US
dc.identifier.citationMartin-Montalvo, A., E. M. Mercken, S. J. Mitchell, H. H. Palacios, P. L. Mote, M. Scheibye-Knudsen, A. P. Gomes, et al. 2013. “Metformin improves healthspan and lifespan in mice.” Nature communications 4 (1): 2192. doi:10.1038/ncomms3192. http://dx.doi.org/10.1038/ncomms3192.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879643
dc.description.abstractMetformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced LDL and cholesterol levels without a decrease in caloric intake. At a molecular level, metformin increases AMP-activated protein kinase activity and increases antioxidant protection, resulting in reductions in both oxidative damage accumulation and chronic inflammation. Our results indicate that these actions may contribute to the beneficial effects of metformin on healthspan and lifespan. These findings are in agreement with current epidemiological data and raise the possibility of metformin-based interventions to promote healthy aging.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncomms3192en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736576/pdf/en
dash.licenseLAAen_US
dc.titleMetformin improves healthspan and lifespan in miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature communicationsen
dash.depositing.authorSinclair, David A.en_US
dc.date.available2014-03-11T13:27:16Z
dc.identifier.doi10.1038/ncomms3192*
dash.authorsorderedfalse
dash.contributor.affiliatedSinclair, David


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