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dc.contributor.authorHadjikhani, Nen_US
dc.contributor.authorZürcher, N Ren_US
dc.contributor.authorRogier, Oen_US
dc.contributor.authorHippolyte, Len_US
dc.contributor.authorLemonnier, Een_US
dc.contributor.authorRuest, Ten_US
dc.contributor.authorWard, Nen_US
dc.contributor.authorLassalle, Aen_US
dc.contributor.authorGillberg, Nen_US
dc.contributor.authorBillstedt, Een_US
dc.contributor.authorHelles, Aen_US
dc.contributor.authorGillberg, Cen_US
dc.contributor.authorSolomon, Pen_US
dc.contributor.authorPrkachin, K Men_US
dc.date.accessioned2014-03-11T13:27:28Z
dc.date.issued2014en_US
dc.identifier.citationHadjikhani, N., N. R. Zürcher, O. Rogier, L. Hippolyte, E. Lemonnier, T. Ruest, N. Ward, et al. 2014. “Emotional contagion for pain is intact in autism spectrum disorders.” Translational Psychiatry 4 (1): e343. doi:10.1038/tp.2013.113. http://dx.doi.org/10.1038/tp.2013.113.en
dc.identifier.issn2158-3188en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879665
dc.description.abstractPerceiving others in pain generally leads to empathic concern, consisting of both emotional and cognitive processes. Empathy deficits have been considered as an element contributing to social difficulties in individuals with autism spectrum disorders (ASD). Here, we used functional magnetic resonance imaging and short video clips of facial expressions of people experiencing pain to examine the neural substrates underlying the spontaneous empathic response to pain in autism. Thirty-eight adolescents and adults of normal intelligence diagnosed with ASD and 35 matched controls participated in the study. In contrast to general assumptions, we found no significant differences in brain activation between ASD individuals and controls during the perception of pain experienced by others. Both groups showed similar levels of activation in areas associated with pain sharing, evidencing the presence of emotional empathy and emotional contagion in participants with autism as well as in controls. Differences between groups could be observed at a more liberal statistical threshold, and revealed increased activations in areas involved in cognitive reappraisal in ASD participants compared with controls. Scores of emotional empathy were positively correlated with brain activation in areas involved in embodiment of pain in ASD group only. Our findings show that simulation mechanisms involved in emotional empathy are preserved in high-functioning individuals with autism, and suggest that increased reappraisal may have a role in their apparent lack of caring behavior.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/tp.2013.113en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905223/pdf/en
dash.licenseLAAen_US
dc.subjectautismen
dc.subjectemotion perceptionen
dc.subjectfMRIen
dc.subjectpainen
dc.titleEmotional contagion for pain is intact in autism spectrum disordersen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalTranslational Psychiatryen
dc.date.available2014-03-11T13:27:28Z
dc.identifier.doi10.1038/tp.2013.113*
dash.authorsorderedfalse


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