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dc.contributor.authorBritton, Kathryn A.en_US
dc.contributor.authorWang, Naen_US
dc.contributor.authorPalmisano, Josephen_US
dc.contributor.authorCorsini, Erinen_US
dc.contributor.authorSchlett, Christopher L.en_US
dc.contributor.authorHoffmann, Udoen_US
dc.contributor.authorLarson, Martin G.en_US
dc.contributor.authorVasan, Ramachandran S.en_US
dc.contributor.authorVita, Joseph A.en_US
dc.contributor.authorMitchell, Gary F.en_US
dc.contributor.authorBenjamin, Emelia J.en_US
dc.contributor.authorHamburg, Naomi M.en_US
dc.contributor.authorFox, Caroline S.en_US
dc.date.accessioned2014-03-11T13:27:28Z
dc.date.issued2013en_US
dc.identifier.citationBritton, K. A., N. Wang, J. Palmisano, E. Corsini, C. L. Schlett, U. Hoffmann, M. G. Larson, et al. 2013. “Thoracic Periaortic and Visceral Adipose Tissue and Their Cross-sectional Associations with Measures of Vascular Function.” Obesity (Silver Spring, Md.) 21 (7): 1496-1503. doi:10.1002/oby.20166. http://dx.doi.org/10.1002/oby.20166.en
dc.identifier.issn1930-7381en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879667
dc.description.abstractObjective: Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) are associated with vascular function. Design and Methods TAT and VAT were quantified in Framingham Heart Study participants using multidetector computed tomography; vascular function was assessed using brachial artery vasodilator function, peripheral arterial tone and arterial tonometry (n= 2735, 48% women, mean age 50 years, mean BMI 27.7 kg/m2). Using multiple linear regression, we examined relations between TAT, VAT, and vascular measures while adjusting for cardiovascular risk factors. Results: Mean TAT and VAT volumes were 13.2 and 1763 cm3. TAT and VAT were associated with multiple vascular function measures after multivariable adjustment. After BMI adjustment, TAT and VAT remained negatively associated with peripheral arterial tone and inverse carotid femoral pulse wave velocity (p<0.02); TAT was negatively associated with hyperemic mean flow velocity (p=0.03). Associations of TAT with vascular function were attenuated after VAT adjustment (all p>0.06). Conclusion: Thoracic periaortic and visceral fat are associated with microvascular function and large artery stiffness after BMI adjustment. These findings support the growing recognition of associations between ectopic fat and vascular function.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1002/oby.20166en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742564/pdf/en
dash.licenseLAAen_US
dc.subjectobesityen
dc.subjectvascular functionen
dc.subjectarterial stiffnessen
dc.subjectperivascular adipose tissueen
dc.subjectvisceral adipose tissueen
dc.titleThoracic Periaortic and Visceral Adipose Tissue and Their Cross-sectional Associations with Measures of Vascular Functionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalObesity (Silver Spring, Md.)en
dash.depositing.authorBritton, Kathryn A.en_US
dc.date.available2014-03-11T13:27:28Z
dc.identifier.doi10.1002/oby.20166*
dash.authorsorderedfalse
dash.contributor.affiliatedBritton, Kathryn
dash.contributor.affiliatedHoffmann, Udo
dash.contributor.affiliatedFox, Caroline


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