Recent Progress in Osteocyte Research

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Recent Progress in Osteocyte Research

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Title: Recent Progress in Osteocyte Research
Author: Divieti Pajevic, Paola
Citation: Divieti Pajevic, Paola. 2013. “Recent Progress in Osteocyte Research.” Endocrinology and Metabolism 28 (4): 255-261. doi:10.3803/EnM.2013.28.4.255. http://dx.doi.org/10.3803/EnM.2013.28.4.255.
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Abstract: The last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral homeostasis, and hematopoiesis. As tools and techniques to study osteocytes improved and expanded, it has become evident that there is more to these cells than initially thought. Osteocytes are now recognized not only as the key responders to mechanical forces but also as orchestrators of bone remodeling and mineral homeostasis. These cells are the primary source of several important proteins, such as sclerostin and fibroblast growth factor 23, that are currently target as novel therapies for bone loss (as the case for antisclerostin antibodies) or phosphate disorders. Better understanding of the intricate cellular and molecular mechanisms that govern osteocyte biology will open new avenue of research and ultimately indentify novel therapeutics to treat bone and mineral disorders. This review summarizes novel findings and discusses future avenues of research.
Published Version: doi:10.3803/EnM.2013.28.4.255
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871031/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879695
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