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dc.contributor.authorDivieti Pajevic, Paolaen_US
dc.date.accessioned2014-03-11T13:27:42Z
dc.date.issued2013en_US
dc.identifier.citationDivieti Pajevic, Paola. 2013. “Recent Progress in Osteocyte Research.” Endocrinology and Metabolism 28 (4): 255-261. doi:10.3803/EnM.2013.28.4.255. http://dx.doi.org/10.3803/EnM.2013.28.4.255.en
dc.identifier.issn2093-596Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879695
dc.description.abstractThe last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral homeostasis, and hematopoiesis. As tools and techniques to study osteocytes improved and expanded, it has become evident that there is more to these cells than initially thought. Osteocytes are now recognized not only as the key responders to mechanical forces but also as orchestrators of bone remodeling and mineral homeostasis. These cells are the primary source of several important proteins, such as sclerostin and fibroblast growth factor 23, that are currently target as novel therapies for bone loss (as the case for antisclerostin antibodies) or phosphate disorders. Better understanding of the intricate cellular and molecular mechanisms that govern osteocyte biology will open new avenue of research and ultimately indentify novel therapeutics to treat bone and mineral disorders. This review summarizes novel findings and discusses future avenues of research.en
dc.language.isoen_USen
dc.publisherKorean Endocrine Societyen
dc.relation.isversionofdoi:10.3803/EnM.2013.28.4.255en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871031/pdf/en
dash.licenseLAAen_US
dc.subjectOsteocytesen
dc.subjectSclerostinen
dc.subjectMineral homeostasisen
dc.subjectBone homeostasisen
dc.titleRecent Progress in Osteocyte Researchen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEndocrinology and Metabolismen
dc.date.available2014-03-11T13:27:42Z
dc.identifier.doi10.3803/EnM.2013.28.4.255*


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